TY - JOUR
T1 - Influence of gray level discretization on radiomic feature stability for different CT scanners, tube currents and slice thicknesses
T2 - 15th Acta Oncologica Symposium - Biology-Guided Adaptive Radiotherapy (BiGART)
AU - Larue, Ruben T. H. M.
AU - van Timmeren, Janna E.
AU - de Jong, Evelyn E. C.
AU - Feliciani, Giacomo
AU - Leijenaar, Ralph T. H.
AU - Schreurs, Wendy M. J.
AU - Sosef, Meindert N.
AU - Raat, Frank H. P. J.
AU - van der Zande, Frans H. R.
AU - Das, Marco
AU - van Elmpt, Wouter
AU - Lambin, Philippe
PY - 2017
Y1 - 2017
N2 - Background: Radiomic analyses of CT images provide prognostic information that can potentially be used for personalized treatment. However, heterogeneity of acquisition-and reconstruction protocols influences robustness of radiomic analyses. The aim of this study was to investigate the influence of different CT-scanners, slice thicknesses, exposures and gray-level discretization on radiomic feature values and their stability.Material and methods: A texture phantom with ten different inserts was scanned on nine different CT-scanners with varying tube currents. Scans were reconstructed with 1.5mm or 3mm slice thickness. Image pre-processing comprised gray-level discretization in ten different bin widths ranging from 5 to 50 HU and different resampling methods (i.e., linear, cubic and nearest neighbor interpolation to 1 x 1 x 3mm(3) voxels) were investigated. Subsequently, 114 textural radiomic features were extracted from a 2.1cm(3) sphere in the center of each insert. The influence of slice thickness, exposure and bin width on feature values was investigated. Feature stability was assessed by calculating the concordance correlation coefficient (CCC) in a test-retest setting and for different combinations of scanners, tube currents and slice thicknesses.Results: Bin width influenced feature values, but this only had a marginal effect on the total number of stable features (CCC>0.85) when comparing different scanners, slice thicknesses or exposures. Most radiomic features were affected by slice thickness, but this effect could be reduced by resampling the CT-images before feature extraction. Statistics feature 'energy' was the most dependent on slice thickness. No clear correlation between feature values and exposures was observed.Conclusions: CT-scanner, slice thickness and bin width affected radiomic feature values, whereas no effect of exposure was observed. Optimization of gray-level discretization to potentially improve prognostic value can be performed without compromising feature stability. Resampling images prior to feature extraction decreases the variability of radiomic features.
AB - Background: Radiomic analyses of CT images provide prognostic information that can potentially be used for personalized treatment. However, heterogeneity of acquisition-and reconstruction protocols influences robustness of radiomic analyses. The aim of this study was to investigate the influence of different CT-scanners, slice thicknesses, exposures and gray-level discretization on radiomic feature values and their stability.Material and methods: A texture phantom with ten different inserts was scanned on nine different CT-scanners with varying tube currents. Scans were reconstructed with 1.5mm or 3mm slice thickness. Image pre-processing comprised gray-level discretization in ten different bin widths ranging from 5 to 50 HU and different resampling methods (i.e., linear, cubic and nearest neighbor interpolation to 1 x 1 x 3mm(3) voxels) were investigated. Subsequently, 114 textural radiomic features were extracted from a 2.1cm(3) sphere in the center of each insert. The influence of slice thickness, exposure and bin width on feature values was investigated. Feature stability was assessed by calculating the concordance correlation coefficient (CCC) in a test-retest setting and for different combinations of scanners, tube currents and slice thicknesses.Results: Bin width influenced feature values, but this only had a marginal effect on the total number of stable features (CCC>0.85) when comparing different scanners, slice thicknesses or exposures. Most radiomic features were affected by slice thickness, but this effect could be reduced by resampling the CT-images before feature extraction. Statistics feature 'energy' was the most dependent on slice thickness. No clear correlation between feature values and exposures was observed.Conclusions: CT-scanner, slice thickness and bin width affected radiomic feature values, whereas no effect of exposure was observed. Optimization of gray-level discretization to potentially improve prognostic value can be performed without compromising feature stability. Resampling images prior to feature extraction decreases the variability of radiomic features.
KW - FDG-PET RADIOMICS
KW - CELL LUNG-CANCER
KW - TEST-RETEST
KW - REPRODUCIBILITY
KW - IMAGES
KW - VARIABILITY
KW - PROGNOSIS
KW - SIGNATURE
U2 - 10.1080/0284186X.2017.1351624
DO - 10.1080/0284186X.2017.1351624
M3 - Article
C2 - 28885084
SN - 0284-186X
VL - 56
SP - 1544
EP - 1553
JO - Acta Oncologica
JF - Acta Oncologica
IS - 11
Y2 - 13 June 2017 through 16 June 2017
ER -