Inflammatory response and bone healing capacity of two porous calcium phosphate ceramics in critical size cortical bone defects

Anindita Chatterjea, Johan van der Stok, Charlene B. Danoux, Huipin Yuan, Pamela Habibovic, Clemens A. van Blitterswijk, Harrie Weinans, Jan de Boer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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In the present study, two open porous calcium phosphate ceramics, ?-tricalcium phosphate (?-TCP), and hydroxyapatite (HA) were compared in a critical-sized femoral defect in rats. Previous comparisons of these two ceramics showed significantly greater osteoinductive potential of ?-TCP upon intramuscular implantation and a better performance in a spinal fusion model in dogs. Results of the current study also showed significantly more bone formation in defects grafted with ?-TCP compared to HA; however, both the ceramics were not capable of increasing bone formation to such extend that it bridges the defect. Furthermore, a more pronounced degradation of ?-TCP was observed as compared to HA. Progression of inflammation and initiation of new bone formation were assessed for both materials at multiple time points by histological and fluorochrome-based analyses. Until 12 days postimplantation, a strong inflammatory response in absence of new bone formation was observed in both ceramics, without obvious differences between the two materials. Four weeks postimplantation, signs of new bone formation were found in both ?-TCP and HA. At 6 weeks, inflammation had subsided in both ceramics while bone deposition continued. In conclusion, the two ceramics differed in the amount of bone formed after 8 weeks of implantation, whereas no differences were found in the duration of the inflammatory phase after implantation or initiation of new bone formation.
Original languageEnglish
Pages (from-to)1399-1407
JournalJournal of Biomedical Materials Research Part A
Issue number5
Publication statusPublished - May 2014


  • inflammatory response
  • osteoinductive potential
  • tricalcium phosphate
  • rat femoral defect
  • hydroxyapatite


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