Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study.

L.H. Jacobs; J.J. van de Kerkhof; A.M. Mingels; V. Lima Passos; V.W. Kleijnen; A.H. Mazairac; F.M. van der Sande; W.K. Wodzig; C.J. Konings; K.M. Leunissen; M.P. van Dieijen-Visser; J.P. Kooman

doi:10.1093/ndt/gfp417

Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study.

L.H. Jacobs^*, J.J. van de Kerkhof, A.M. Mingels, V. Lima Passos, V.W. Kleijnen, A.H. Mazairac, F.M. van der Sande, W.K. Wodzig, C.J. Konings, K.M. Leunissen, M.P. van Dieijen-Visser, J.P. Kooman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Inflammation, overhydration and elevated cardiac biomarkers are related to outcome in haemodialysis (HD) patients. Here, we explored the relationship between the body composition (BC), inflammation and cardiac biomarker concentrations in HD patients longitudinally. METHODS: A total of 44 HD patients were followed for 6 months. BC was assessed by multifrequency bioimpedance (BIA). Serum concentrations of cardiac troponin T (cTnT), high-sensitive C-reactive protein (hsCRP), brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) were assessed at 2 monthly intervals. The longitudinal data analysis was conducted with a marginal model. RESULTS: During the follow-up, the parameters describing the BC were highly predictive of both BNP and NT-proBNP and independent of gender, time, hsCRP and cTnT concentrations. The intracellular water (ICW)/body weight (BW) ratio (reflecting malnutrition) exerted a negative effect, whereas the extracellular water (ECW)/BW ratio (reflecting overhydration) had a positive effect on BNP and NT-proBNP concentrations. HsCRP and cTnT concentrations were significantly associated with each other. Furthermore, NT-proBNP concentrations were predictive of cTnT and hsCRP concentrations. CONCLUSIONS: In the present study, we find a significant relation between BIA-derived BC parameters and natriuretic peptide concentrations. This relationship was independent of the cardiac history of the patient and suggests that the natriuretic peptide levels are to some degree modifiable by changing a patient's fluid distribution. Moreover, cTnT, BNP, NT-proBNP and hsCRP were significantly related, showing a complex relation between overhydration, malnutrition, inflammation and cardiac biomarkers in dialysis patients.

Original language	English
Pages (from-to)	243-248
Number of pages	6
Journal	Nephrology Dialysis Transplantation
Volume	25
Issue number	1
DOIs	https://doi.org/10.1093/ndt/gfp417
Publication status	Published - 1 Jan 2010

Keywords

bioimpedance
haemodialysis
natriuretic peptides
overhydration
troponin
PERITONEAL-DIALYSIS PATIENTS
TROPONIN-T ELEVATION
LEFT-VENTRICULAR DYSFUNCTION
RESIDUAL RENAL-FUNCTION
CHRONIC KIDNEY-DISEASE
NATRIURETIC PEPTIDE
PREDICTS MORTALITY
NUTRITIONAL-STATUS
HEART-FAILURE
VOLUME STATUS

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10.1093/ndt/gfp417

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Jacobs, L. H., van de Kerkhof, J. J., Mingels, A. M., Lima Passos, V., Kleijnen, V. W., Mazairac, A. H., van der Sande, F. M., Wodzig, W. K., Konings, C. J., Leunissen, K. M., van Dieijen-Visser, M. P., & Kooman, J. P. (2010). Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study. Nephrology Dialysis Transplantation, 25(1), 243-248. https://doi.org/10.1093/ndt/gfp417

@article{263391dd792a431e8157d2a155e4e6a8,

title = "Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study.",

abstract = "BACKGROUND: Inflammation, overhydration and elevated cardiac biomarkers are related to outcome in haemodialysis (HD) patients. Here, we explored the relationship between the body composition (BC), inflammation and cardiac biomarker concentrations in HD patients longitudinally. METHODS: A total of 44 HD patients were followed for 6 months. BC was assessed by multifrequency bioimpedance (BIA). Serum concentrations of cardiac troponin T (cTnT), high-sensitive C-reactive protein (hsCRP), brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) were assessed at 2 monthly intervals. The longitudinal data analysis was conducted with a marginal model. RESULTS: During the follow-up, the parameters describing the BC were highly predictive of both BNP and NT-proBNP and independent of gender, time, hsCRP and cTnT concentrations. The intracellular water (ICW)/body weight (BW) ratio (reflecting malnutrition) exerted a negative effect, whereas the extracellular water (ECW)/BW ratio (reflecting overhydration) had a positive effect on BNP and NT-proBNP concentrations. HsCRP and cTnT concentrations were significantly associated with each other. Furthermore, NT-proBNP concentrations were predictive of cTnT and hsCRP concentrations. CONCLUSIONS: In the present study, we find a significant relation between BIA-derived BC parameters and natriuretic peptide concentrations. This relationship was independent of the cardiac history of the patient and suggests that the natriuretic peptide levels are to some degree modifiable by changing a patient's fluid distribution. Moreover, cTnT, BNP, NT-proBNP and hsCRP were significantly related, showing a complex relation between overhydration, malnutrition, inflammation and cardiac biomarkers in dialysis patients.",

keywords = "bioimpedance, haemodialysis, natriuretic peptides, overhydration, troponin, PERITONEAL-DIALYSIS PATIENTS, TROPONIN-T ELEVATION, LEFT-VENTRICULAR DYSFUNCTION, RESIDUAL RENAL-FUNCTION, CHRONIC KIDNEY-DISEASE, NATRIURETIC PEPTIDE, PREDICTS MORTALITY, NUTRITIONAL-STATUS, HEART-FAILURE, VOLUME STATUS",

author = "L.H. Jacobs and {van de Kerkhof}, J.J. and A.M. Mingels and {Lima Passos}, V. and V.W. Kleijnen and A.H. Mazairac and {van der Sande}, F.M. and W.K. Wodzig and C.J. Konings and K.M. Leunissen and {van Dieijen-Visser}, M.P. and J.P. Kooman",

year = "2010",

month = jan,

day = "1",

doi = "10.1093/ndt/gfp417",

language = "English",

volume = "25",

pages = "243--248",

journal = "Nephrology Dialysis Transplantation",

issn = "0931-0509",

publisher = "Oxford University Press",

number = "1",

}

Jacobs, LH, van de Kerkhof, JJ, Mingels, AM, Lima Passos, V, Kleijnen, VW, Mazairac, AH, van der Sande, FM, Wodzig, WK, Konings, CJ, Leunissen, KM, van Dieijen-Visser, MP & Kooman, JP 2010, 'Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study.', Nephrology Dialysis Transplantation, vol. 25, no. 1, pp. 243-248. https://doi.org/10.1093/ndt/gfp417

TY - JOUR

T1 - Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study.

AU - Jacobs, L.H.

AU - van de Kerkhof, J.J.

AU - Mingels, A.M.

AU - Lima Passos, V.

AU - Kleijnen, V.W.

AU - Mazairac, A.H.

AU - van der Sande, F.M.

AU - Wodzig, W.K.

AU - Konings, C.J.

AU - Leunissen, K.M.

AU - van Dieijen-Visser, M.P.

AU - Kooman, J.P.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - BACKGROUND: Inflammation, overhydration and elevated cardiac biomarkers are related to outcome in haemodialysis (HD) patients. Here, we explored the relationship between the body composition (BC), inflammation and cardiac biomarker concentrations in HD patients longitudinally. METHODS: A total of 44 HD patients were followed for 6 months. BC was assessed by multifrequency bioimpedance (BIA). Serum concentrations of cardiac troponin T (cTnT), high-sensitive C-reactive protein (hsCRP), brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) were assessed at 2 monthly intervals. The longitudinal data analysis was conducted with a marginal model. RESULTS: During the follow-up, the parameters describing the BC were highly predictive of both BNP and NT-proBNP and independent of gender, time, hsCRP and cTnT concentrations. The intracellular water (ICW)/body weight (BW) ratio (reflecting malnutrition) exerted a negative effect, whereas the extracellular water (ECW)/BW ratio (reflecting overhydration) had a positive effect on BNP and NT-proBNP concentrations. HsCRP and cTnT concentrations were significantly associated with each other. Furthermore, NT-proBNP concentrations were predictive of cTnT and hsCRP concentrations. CONCLUSIONS: In the present study, we find a significant relation between BIA-derived BC parameters and natriuretic peptide concentrations. This relationship was independent of the cardiac history of the patient and suggests that the natriuretic peptide levels are to some degree modifiable by changing a patient's fluid distribution. Moreover, cTnT, BNP, NT-proBNP and hsCRP were significantly related, showing a complex relation between overhydration, malnutrition, inflammation and cardiac biomarkers in dialysis patients.

AB - BACKGROUND: Inflammation, overhydration and elevated cardiac biomarkers are related to outcome in haemodialysis (HD) patients. Here, we explored the relationship between the body composition (BC), inflammation and cardiac biomarker concentrations in HD patients longitudinally. METHODS: A total of 44 HD patients were followed for 6 months. BC was assessed by multifrequency bioimpedance (BIA). Serum concentrations of cardiac troponin T (cTnT), high-sensitive C-reactive protein (hsCRP), brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) were assessed at 2 monthly intervals. The longitudinal data analysis was conducted with a marginal model. RESULTS: During the follow-up, the parameters describing the BC were highly predictive of both BNP and NT-proBNP and independent of gender, time, hsCRP and cTnT concentrations. The intracellular water (ICW)/body weight (BW) ratio (reflecting malnutrition) exerted a negative effect, whereas the extracellular water (ECW)/BW ratio (reflecting overhydration) had a positive effect on BNP and NT-proBNP concentrations. HsCRP and cTnT concentrations were significantly associated with each other. Furthermore, NT-proBNP concentrations were predictive of cTnT and hsCRP concentrations. CONCLUSIONS: In the present study, we find a significant relation between BIA-derived BC parameters and natriuretic peptide concentrations. This relationship was independent of the cardiac history of the patient and suggests that the natriuretic peptide levels are to some degree modifiable by changing a patient's fluid distribution. Moreover, cTnT, BNP, NT-proBNP and hsCRP were significantly related, showing a complex relation between overhydration, malnutrition, inflammation and cardiac biomarkers in dialysis patients.

KW - bioimpedance

KW - haemodialysis

KW - natriuretic peptides

KW - overhydration

KW - troponin

KW - PERITONEAL-DIALYSIS PATIENTS

KW - TROPONIN-T ELEVATION

KW - LEFT-VENTRICULAR DYSFUNCTION

KW - RESIDUAL RENAL-FUNCTION

KW - CHRONIC KIDNEY-DISEASE

KW - NATRIURETIC PEPTIDE

KW - PREDICTS MORTALITY

KW - NUTRITIONAL-STATUS

KW - HEART-FAILURE

KW - VOLUME STATUS

U2 - 10.1093/ndt/gfp417

DO - 10.1093/ndt/gfp417

M3 - Article

C2 - 19692417

SN - 0931-0509

VL - 25

SP - 243

EP - 248

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

IS - 1

ER -

Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study.

Abstract

Keywords

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