Abstract
We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can he upregulated by inflammation, probably via the JAK/STAT3 pathway.
Original language | English |
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Article number | e04114 |
Number of pages | 4 |
Journal | Clinical Case Reports |
Volume | 9 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 May 2021 |
Keywords
- hemochromatosis
- hepcidin
- inflammation
- iron overload
- IRON
- EXPRESSION
- PATHWAY