We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can he upregulated by inflammation, probably via the JAK/STAT3 pathway.
|Number of pages||4|
|Journal||Clinical Case Reports|
|Publication status||Published - 1 May 2021|
- iron overload