Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation

Karen K. Ballen; Kwang Woo Ahn; Wei-Min Chen; Hisham Abdel-Azim; Ibrahim Ahmed; Mahmoud D. Aljurf; Joseph H. Antin; Ami S. Bhatt; Michael Boeckh; George Chen; Christopher Dandoy; Biju George; Mary. J. Laughlin; Hillard M. Lazarus; Margaret L. MacMillan; David A. Margolis; David I. Marks; Maxim Norkin; Joseph Rosenthal; Ayman Saad; Bipin N. Savani; Hendricus Schouten; Jan Storek; Paul Szabolcs; Celalettin Ustun; Michael R. Verneris; Edmund K. Waller; Daniel J. Weisdorf; Kirsten M. Williams; John R. Wingard; Baldeep M. Wirk; Tom Wolfs; Jo-Anne H. Young; Jeffrey Auletta; Krishna V. Komanduri; Caroline Lindemans; Marcie L. Riches

doi:10.1016/j.bbmt.2016.06.012

Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation

Karen K. Ballen^*, Kwang Woo Ahn, Wei-Min Chen, Hisham Abdel-Azim, Ibrahim Ahmed, Mahmoud D. Aljurf, Joseph H. Antin, Ami S. Bhatt, Michael Boeckh, George Chen, Christopher Dandoy, Biju George, Mary. J. Laughlin, Hillard M. Lazarus, Margaret L. MacMillan, David A. Margolis, David I. Marks, Maxim Norkin, Joseph Rosenthal, Ayman SaadBipin N. Savani, Hendricus Schouten, Jan Storek, Paul Szabolcs, Celalettin Ustun, Michael R. Verneris, Edmund K. Waller, Daniel J. Weisdorf, Kirsten M. Williams, John R. Wingard, Baldeep M. Wirk, Tom Wolfs, Jo-Anne H. Young, Jeffrey Auletta, Krishna V. Komanduri, Caroline Lindemans, Marcie L. Riches

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Alternative graft sources (umbilical cord blood [UCB], matched unrelated donors [MUD], or mismatched unrelated donors [MMUD]) enable patients without a matched sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different graft sources. However, the risk and types of infections have not been compared among graft sources. Such information may influence the choice of a particular graft source. We compared the incidence of bacterial, viral, and fungal infections in 1781 adults with acute leukemia who received alternative donor HCT (UCB, n=?568; MUD, n?=?930; MMUD, n?=?283) between 2008 and 2011. The incidences of bacterial infection at 1 year were 72%, 59%, and 65% (P?

Original language	English
Pages (from-to)	1636-1645
Journal	Biology of Blood and Marrow Transplantation
Volume	22
Issue number	9
DOIs	https://doi.org/10.1016/j.bbmt.2016.06.012
Publication status	Published - Sept 2016

Keywords

Umbilical cord blood
Leukemia
Infection

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10.1016/j.bbmt.2016.06.012Licence: CC BY-NC-ND

Cite this

Ballen, K. K., Ahn, K. W., Chen, W.-M., Abdel-Azim, H., Ahmed, I., Aljurf, M. D., Antin, J. H., Bhatt, A. S., Boeckh, M., Chen, G., Dandoy, C., George, B., Laughlin, M. J., Lazarus, H. M., MacMillan, M. L., Margolis, D. A., Marks, D. I., Norkin, M., Rosenthal, J., ... Riches, M. L. (2016). Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation, 22(9), 1636-1645. https://doi.org/10.1016/j.bbmt.2016.06.012

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title = "Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation",

abstract = "Alternative graft sources (umbilical cord blood [UCB], matched unrelated donors [MUD], or mismatched unrelated donors [MMUD]) enable patients without a matched sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different graft sources. However, the risk and types of infections have not been compared among graft sources. Such information may influence the choice of a particular graft source. We compared the incidence of bacterial, viral, and fungal infections in 1781 adults with acute leukemia who received alternative donor HCT (UCB, n=?568; MUD, n?=?930; MMUD, n?=?283) between 2008 and 2011. The incidences of bacterial infection at 1 year were 72%, 59%, and 65% (P?",

keywords = "Umbilical cord blood, Leukemia, Infection",

author = "Ballen, {Karen K.} and Ahn, {Kwang Woo} and Wei-Min Chen and Hisham Abdel-Azim and Ibrahim Ahmed and Aljurf, {Mahmoud D.} and Antin, {Joseph H.} and Bhatt, {Ami S.} and Michael Boeckh and George Chen and Christopher Dandoy and Biju George and Laughlin, {Mary. J.} and Lazarus, {Hillard M.} and MacMillan, {Margaret L.} and Margolis, {David A.} and Marks, {David I.} and Maxim Norkin and Joseph Rosenthal and Ayman Saad and Savani, {Bipin N.} and Hendricus Schouten and Jan Storek and Paul Szabolcs and Celalettin Ustun and Verneris, {Michael R.} and Waller, {Edmund K.} and Weisdorf, {Daniel J.} and Williams, {Kirsten M.} and Wingard, {John R.} and Wirk, {Baldeep M.} and Tom Wolfs and Young, {Jo-Anne H.} and Jeffrey Auletta and Komanduri, {Krishna V.} and Caroline Lindemans and Riches, {Marcie L.}",

year = "2016",

month = sep,

doi = "10.1016/j.bbmt.2016.06.012",

language = "English",

volume = "22",

pages = "1636--1645",

journal = "Biology of Blood and Marrow Transplantation",

issn = "1083-8791",

publisher = "Elsevier Science",

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Ballen, KK, Ahn, KW, Chen, W-M, Abdel-Azim, H, Ahmed, I, Aljurf, MD, Antin, JH, Bhatt, AS, Boeckh, M, Chen, G, Dandoy, C, George, B, Laughlin, MJ, Lazarus, HM, MacMillan, ML, Margolis, DA, Marks, DI, Norkin, M, Rosenthal, J, Saad, A, Savani, BN, Schouten, H, Storek, J, Szabolcs, P, Ustun, C, Verneris, MR, Waller, EK, Weisdorf, DJ, Williams, KM, Wingard, JR, Wirk, BM, Wolfs, T, Young, J-AH, Auletta, J, Komanduri, KV, Lindemans, C & Riches, ML 2016, 'Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation', Biology of Blood and Marrow Transplantation, vol. 22, no. 9, pp. 1636-1645. https://doi.org/10.1016/j.bbmt.2016.06.012

TY - JOUR

T1 - Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation

AU - Ballen, Karen K.

AU - Ahn, Kwang Woo

AU - Chen, Wei-Min

AU - Abdel-Azim, Hisham

AU - Ahmed, Ibrahim

AU - Aljurf, Mahmoud D.

AU - Antin, Joseph H.

AU - Bhatt, Ami S.

AU - Boeckh, Michael

AU - Chen, George

AU - Dandoy, Christopher

AU - George, Biju

AU - Laughlin, Mary. J.

AU - Lazarus, Hillard M.

AU - MacMillan, Margaret L.

AU - Margolis, David A.

AU - Marks, David I.

AU - Norkin, Maxim

AU - Rosenthal, Joseph

AU - Saad, Ayman

AU - Savani, Bipin N.

AU - Schouten, Hendricus

AU - Storek, Jan

AU - Szabolcs, Paul

AU - Ustun, Celalettin

AU - Verneris, Michael R.

AU - Waller, Edmund K.

AU - Weisdorf, Daniel J.

AU - Williams, Kirsten M.

AU - Wingard, John R.

AU - Wirk, Baldeep M.

AU - Wolfs, Tom

AU - Young, Jo-Anne H.

AU - Auletta, Jeffrey

AU - Komanduri, Krishna V.

AU - Lindemans, Caroline

AU - Riches, Marcie L.

PY - 2016/9

Y1 - 2016/9

N2 - Alternative graft sources (umbilical cord blood [UCB], matched unrelated donors [MUD], or mismatched unrelated donors [MMUD]) enable patients without a matched sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different graft sources. However, the risk and types of infections have not been compared among graft sources. Such information may influence the choice of a particular graft source. We compared the incidence of bacterial, viral, and fungal infections in 1781 adults with acute leukemia who received alternative donor HCT (UCB, n=?568; MUD, n?=?930; MMUD, n?=?283) between 2008 and 2011. The incidences of bacterial infection at 1 year were 72%, 59%, and 65% (P?

AB - Alternative graft sources (umbilical cord blood [UCB], matched unrelated donors [MUD], or mismatched unrelated donors [MMUD]) enable patients without a matched sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different graft sources. However, the risk and types of infections have not been compared among graft sources. Such information may influence the choice of a particular graft source. We compared the incidence of bacterial, viral, and fungal infections in 1781 adults with acute leukemia who received alternative donor HCT (UCB, n=?568; MUD, n?=?930; MMUD, n?=?283) between 2008 and 2011. The incidences of bacterial infection at 1 year were 72%, 59%, and 65% (P?

KW - Umbilical cord blood

KW - Leukemia

KW - Infection

U2 - 10.1016/j.bbmt.2016.06.012

DO - 10.1016/j.bbmt.2016.06.012

M3 - Article

C2 - 27343716

SN - 1083-8791

VL - 22

SP - 1636

EP - 1645

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 9

ER -