Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation

Karen K. Ballen*, Kwang Woo Ahn, Wei-Min Chen, Hisham Abdel-Azim, Ibrahim Ahmed, Mahmoud D. Aljurf, Joseph H. Antin, Ami S. Bhatt, Michael Boeckh, George Chen, Christopher Dandoy, Biju George, Mary. J. Laughlin, Hillard M. Lazarus, Margaret L. MacMillan, David A. Margolis, David I. Marks, Maxim Norkin, Joseph Rosenthal, Ayman SaadBipin N. Savani, Hendricus Schouten, Jan Storek, Paul Szabolcs, Celalettin Ustun, Michael R. Verneris, Edmund K. Waller, Daniel J. Weisdorf, Kirsten M. Williams, John R. Wingard, Baldeep M. Wirk, Tom Wolfs, Jo-Anne H. Young, Jeffrey Auletta, Krishna V. Komanduri, Caroline Lindemans, Marcie L. Riches

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Web of Science)

Abstract

Alternative graft sources (umbilical cord blood [UCB], matched unrelated donors [MUD], or mismatched unrelated donors [MMUD]) enable patients without a matched sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different graft sources. However, the risk and types of infections have not been compared among graft sources. Such information may influence the choice of a particular graft source. We compared the incidence of bacterial, viral, and fungal infections in 1781 adults with acute leukemia who received alternative donor HCT (UCB, n=?568; MUD, n?=?930; MMUD, n?=?283) between 2008 and 2011. The incidences of bacterial infection at 1 year were 72%, 59%, and 65% (P?
Original languageEnglish
Pages (from-to)1636-1645
JournalBiology of Blood and Marrow Transplantation
Volume22
Issue number9
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Umbilical cord blood
  • Leukemia
  • Infection

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