Infection Prevention In Sarcoidosis: Proposal For Vaccination And Prophylactic Therapy

H. Syed*, C. Ascoli, C.F.M. Linssen, C. Vagts, T. Iden, A. Syed, J. Kron, K. Polly, D. Perkins, P.W. Finn, R. Novak, M. Drent, R. Baughman, N.J. Sweiss

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Citations (Web of Science)

Abstract

Sarcoidosis is a systemic inflammatory disease characterized by granuloma formation in affected organs and caused by dysregulated immune response to an unknown antigen. Sarcoidosis patients receiving immunosuppressive medications are at increased risk of infection. Lymphopenia is also commonly seen among patient with sarcoidosis. In this review, risk of infections, including opportunistic infections, will be outlined. Recommendations for vaccinations and prophylactic therapy based on literature review will also be summarized.
Original languageEnglish
Pages (from-to)87-98
Number of pages12
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume37
Issue number2
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • sarcoidosis
  • infections
  • opportunistic infections
  • vaccinations
  • immunizations
  • prophylaxis
  • travel
  • progressive multifocal leukoencephalopathy
  • immunoglobulin replacement therapy
  • secondary antibody deficiency
  • long-term safety
  • rheumatoid-arthritis
  • herpes-zoster
  • serious infections
  • fungal-infections
  • 1st manifestation
  • united-states
  • RHEUMATOID-ARTHRITIS
  • SECONDARY ANTIBODY DEFICIENCY
  • HERPES-ZOSTER
  • SERIOUS INFECTIONS
  • UNITED-STATES
  • Sarcoidosis
  • FUNGAL-INFECTIONS
  • 1ST MANIFESTATION
  • PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
  • IMMUNOGLOBULIN REPLACEMENT THERAPY
  • LONG-TERM SAFETY

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