Infection prevention in intensive care patients: probiotics compared to antibiotics

Research output: ThesisDoctoral ThesisInternal

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Intensive Care (IC) patients are very vulnerable, which makes them susceptible to infections. Infection prevention is therefore a necessity. Potentially pathogenic bacteria in the gastro-intestinal tract are an important source of infections. These can be tackled by administering antibiotics (this is called selective decontamination of the gastro-intestinal tract – SDD) or by probiotics (living micro-organisms with a healthy effect). Both interventions have pros and cons. A direct comparison shows that equivalence of the probiotic Lactobacillus plantarum 299/299v with regard to SDD concerning infection prevention cannot be proven. No increase in mortality risk can be shown with this probiotic.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Bruggeman, Catharina, Supervisor
  • Stobberingh, Ellen, Co-Supervisor
  • Verbon, Annelies, Co-Supervisor
Award date17 Feb 2012
Place of PublicationMaastricht
Print ISBNs978 94 6159 112 8
Publication statusPublished - 1 Jan 2012


  • : infection prevention in IC
  • SDD
  • probiotics

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