Induction of skin sensitization is augmented in Nrf2-deficient mice

Jochem W. van der Veen*, Eric R. Gremmer, Jolanda P. Vermeulen, Henk van Loveren, Janine Ezendam

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.
Original languageEnglish
Pages (from-to)763-766
JournalArchives of Toxicology
Volume87
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Skin sensitization
  • LLNA
  • Nrf2-deficient
  • In vivo

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