Induction of skin sensitization is augmented in Nrf2-deficient mice

Jochem W. van der Veen; Eric R. Gremmer; Jolanda P. Vermeulen; Henk van Loveren; Janine Ezendam

doi:10.1007/s00204-012-0976-2

Induction of skin sensitization is augmented in Nrf2-deficient mice

Jochem W. van der Veen^*, Eric R. Gremmer, Jolanda P. Vermeulen, Henk van Loveren, Janine Ezendam

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Web of Science)

Abstract

Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

Original language	English
Pages (from-to)	763-766
Journal	Archives of Toxicology
Volume	87
Issue number	4
DOIs	https://doi.org/10.1007/s00204-012-0976-2
Publication status	Published - Apr 2013

Keywords

Skin sensitization
LLNA
Nrf2-deficient
In vivo

Access to Document

10.1007/s00204-012-0976-2

Cite this

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title = "Induction of skin sensitization is augmented in Nrf2-deficient mice",

abstract = "Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.",

keywords = "Skin sensitization, LLNA, Nrf2-deficient, In vivo",

author = "{van der Veen}, {Jochem W.} and Gremmer, {Eric R.} and Vermeulen, {Jolanda P.} and {van Loveren}, Henk and Janine Ezendam",

year = "2013",

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doi = "10.1007/s00204-012-0976-2",

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journal = "Archives of Toxicology",

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T1 - Induction of skin sensitization is augmented in Nrf2-deficient mice

AU - van der Veen, Jochem W.

AU - Gremmer, Eric R.

AU - Vermeulen, Jolanda P.

AU - van Loveren, Henk

AU - Ezendam, Janine

PY - 2013/4

Y1 - 2013/4

N2 - Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

AB - Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

KW - Skin sensitization

KW - LLNA

KW - Nrf2-deficient

KW - In vivo

U2 - 10.1007/s00204-012-0976-2

DO - 10.1007/s00204-012-0976-2

M3 - Article

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SN - 0340-5761

VL - 87

SP - 763

EP - 766

JO - Archives of Toxicology

JF - Archives of Toxicology

IS - 4

ER -