Individually shortened duration versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome: a cost-effectiveness analysis

Elham E. Amin*, Arina J. ten Cate-Hoek, Annemieke C. Bouman, Karina Meijer, Lidwine Tick, Saskia Middeldorp, Guy Mostard, Marije ten Wolde, Simone van den Heiligenberg, Sanne van Wissen, Marlene van de Poet, Sabina Villalta, Erik Serne, Hans Martin Otten, Edith Klappe, Paolo Prandoni, Martin H. Prins, Hugo ten Cate, Manuela A. Joore

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

79 Downloads (Pure)


Background The IDEAL DVT study showed that it was safe to shorten the duration of elastic compression therapy on an individualised basis after deep vein thrombosis for prevention of post-thrombotic syndrome. In this study, we assessed the cost-effectiveness of this strategy.

Methods IDEAL DVT was a multicentre, randomised, non-inferiority trial that included patients with acute proximal deep vein thrombosis of the leg. After 6 months of elastic compression therapy, patients were randomly assigned (1: 1) to the standard 2 years of elastic stocking compression therapy or shortened duration of compression therapy based on the patient's Villalta score. For our cost-effectiveness analysis, we assessed quality-adjusted life-years (QALYs), measured with the three-level version of EQ-5D (EQ-5D-3L; Dutch and UK tariff) and the 36-item Short Form Health Survey (SF-36), and costs in (SIC) (health-care and societal perspective) according to the intention-to-treat approach. Data were collected at 3, 6, 12, and 24 months after diagnosis of thrombosis. We calculated incremental net monetary benefit using a QALY threshold of (SIC) 30 000, and obtained bootstrapped means and 95% CIs. IDEAL DVT is registered with, number NCT01429714.

Findings Between March 22, 2011, and July 1, 2015, 865 patients were enrolled in IDEAL DVT. 437 were assigned to individualised duration of elastic compression therapy and 428 to standard duration of elastic compression therapy. Nine patients were eventually excluded because of recurrent venous thromboembolism within 6 months after the first event. From a societal perspective, for every QALY lost measured with the EQ-5D Dutch tariff, cost savings were (SIC) 305 center dot 992 (incremental net monetary benefit (SIC) 3205, 95% CI 502-5741), and for every QALY lost based on the Short-Form Six-Dimension (SF-6D) utility score (derived from SF-36), cost savings were (SIC) 6030.941 ((SIC) 3540, 95% CI 1174-5953). Using the UK tariff for EQ-5D, the individualised strategy was more effective and less costly ((SIC) 4071, 1452-6647). The probability that the individualised strategy was cost-effective was 99% at a threshold of (SIC) 30 000 per QALY (EQ-5D Dutch tariff).

Interpretation Individually shortened duration of elastic compression therapy was cost-effective compared with standard duration elastic compression therapy. Use of an individualised approach to elastic stocking compression therapy for the prevention of post-thrombotic syndrome after deep vein thrombosis could lead to substantial costs savings without loss in health-related quality of life.Copyright (C) 2018 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)E512-E519
Number of pages8
JournalThe Lancet Haematology
Issue number11
Publication statusPublished - Nov 2018



Cite this