Individualized parcellation of the subthalamic nucleus in patients with Parkinson's disease with 7T MRI

Birgit R. Plantinga, Yasin Temel*, Yuval Duchin, Kamil Uludag, Remi Patriat, Alard Roebroeck, Mark Kuijf, Ali Jahanshahi, Bart ter Haar Romenij, Jerrold Vitekh, Noam Harel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Deep brain stimulation of the subthalamic nucleus (STN) is a widely performed surgical treatment for patients with Parkinson's disease. The goal of the surgery is to place an electrode centered in the motor region of the STN while lowering the effects of electrical stimulation on the non-motor regions. However, distinguishing the motor region from the neighboring associative and limbic areas in individual patients using imaging modalities was until recently difficult to obtain in vivo. Here, using ultra-high field MR imaging, we have performed a dissection of the subdivisions of the STN of individual Parkinson's disease patients. We have acquired 7T diffusion-weighted images of seventeen patients with Parkinson's disease scheduled for deep brain stimulation surgery. Using a structural connectivity-based parcellation protocol, the STN's connections to the motor, limbic, and associative cortical areas were used to map the individual subdivisions of the nucleus. A reproducible patient-specific parcellation of the STN into a posterolateral motor and gradually overlapping central associative area was found in all STNs, taking up on average 55.3% and 55.6% of the total nucleus volume. The limbic area was found in the anteromedial part of the nucleus. Our results suggest that 7T MR imaging may facilitate individualized and highly specific planning of deep brain stimulation surgery of the STN.

Original languageEnglish
Pages (from-to)403-411
Number of pages9
JournalNeuroimage
Volume168
Early online date26 Sep 2016
DOIs
Publication statusPublished - Mar 2018

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