Individualized accelerated isotoxic concurrent chemo-radiotherapy for stage III non-small cell lung cancer: 5-Year results of a prospective study

Dirk De Ruysscher*, Angela van Baardwijk, Rinus Wanders, Lizza E. Hendriks, Bart Reymen, Wouter van Empt, Michel C. Ollers, Gerben Bootsma, Cordula Pitz, Linda van Eijsden, Anne-Marie C. Dingemans

*Corresponding author for this work

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Abstract

Background: Stage III non-small cell lung cancer (NSCLC) still has a poor prognosis. Prior studies with individualized, accelerated, isotoxic dose escalation (INDAR) with 3D-CRT showed promising results, especially in patients not treated with concurrent chemo-radiotherapy. We investigated if INDAR delivered with IMRT would improve the overall survival (OS) of stage III NSCLC patients treated with concurrent chemotherapy and radiotherapy.

Patients and methods: Patients eligible for concurrent chemo-radiotherapy were entered in this prospective study. Radiotherapy was given to a dose of 45 Gy/30 fractions BID (1.5 Gy/fraction), followed by QD fractions of 2 Gy until a total dose determined by the normal tissue constraints. The primary endpoint was OS, secondary endpoints were loco-regional relapses and toxicity.

Results: From May 4, 2009 until April 26, 2012, 185 patients were included. The mean tumor dose was 66.0 +/- 12.8 Gy (36-73 Gy), delivered in a mean of 39.7 fractions in an overall treatment time of 38.2 days. The mean lung dose (MLD) was 17.3 Gy. The median OS was 19.8 months (95% CI 17.3-22.3) with a 5-year OS of 24.3%. Loco-regional failures as first site of recurrence occurred in 59/185 patients (31.8%). Isolated nodal failures (INF) were observed in 3/185 patients (1.6%). Dyspnea grade 3 was seen in 3.2% of patients and transient dysphagia grade 3 in 22%.

Conclusions: INDAR with IMRT concurrently with chemotherapy did not lead to a sign of an improved OS in unselected stage III NSCLC patients. (C) 2019 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalRadiotherapy and Oncology
Volume135
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Non-small cell lung cancer
  • Individualized radiotherapy
  • Concurrent chemotherapy radiotherapy
  • Phase II trial
  • Prospective
  • NORMAL TISSUE CONSTRAINTS
  • LOCALLY ADVANCED HEAD
  • LONG-TERM SURVIVAL
  • RADIATION-THERAPY
  • PHASE-III
  • DOSE-ESCALATION
  • RADIOTHERAPY
  • CHEMOTHERAPY
  • TRIAL
  • CISPLATIN

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