TY - JOUR
T1 - Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk
AU - Lowensteyn, Yvette Nicole
AU - Jansen, Nicolaas Johannes Georgius
AU - van Heerde, Marc
AU - Klein, Richard Henryk
AU - Kneyber, Martin Christiaan Jacques
AU - Kuiper, Jan Willem
AU - Riedijk, Maaike Anne
AU - Verlaat, Carin Wilhelmus Maria
AU - Visser, Idse Hendrik Egbert
AU - van Waardenburg, Dirk Adriaan
AU - van Hasselt, Peter Marin
PY - 2019/7
Y1 - 2019/7
N2 - Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin K deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 to 150g because of a high failure rate. To evaluate the efficacy of this new regimen, incidences of intracranial VKDB under both regimens were compared using both general and targeted surveillance. Late VKDB in the general pediatric population was identified by the Netherlands Pediatric Surveillance Unit, between 1 October 2014 and 31 December 2016. Additionally, infants with intracranial vitamin K deficiency bleeding were identified using the Dutch Pediatric Intensive Care Evaluation registry. The incidence of intracranial VKDB as assessed by general and targeted surveillance decreased from 1.6 per 100,000 (95% CI, 0.4-5.1) to 1.3 per 100,000 (95% CI, 0.5-3.2) and from 3.1 per 100,000 live births (95% CI, 1.9-5.0) to 1.2 per 100,000 live births (95% CI, 0.6-2.3), respectively. Median time between consecutive cases in the latter increased from 24 to 154days (p
AB - Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin K deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 to 150g because of a high failure rate. To evaluate the efficacy of this new regimen, incidences of intracranial VKDB under both regimens were compared using both general and targeted surveillance. Late VKDB in the general pediatric population was identified by the Netherlands Pediatric Surveillance Unit, between 1 October 2014 and 31 December 2016. Additionally, infants with intracranial vitamin K deficiency bleeding were identified using the Dutch Pediatric Intensive Care Evaluation registry. The incidence of intracranial VKDB as assessed by general and targeted surveillance decreased from 1.6 per 100,000 (95% CI, 0.4-5.1) to 1.3 per 100,000 (95% CI, 0.5-3.2) and from 3.1 per 100,000 live births (95% CI, 1.9-5.0) to 1.2 per 100,000 live births (95% CI, 0.6-2.3), respectively. Median time between consecutive cases in the latter increased from 24 to 154days (p
KW - Biliary atresia
KW - Intracranial bleeding
KW - Pediatric intensive care unit
KW - Vitamin K prophylaxis
KW - Vitamin K deficiency bleeding
KW - PREVENTION
KW - REFUSAL
KW - INFANTS
KW - VKDB
U2 - 10.1007/s00431-019-03391-y
DO - 10.1007/s00431-019-03391-y
M3 - Article
C2 - 31062090
SN - 0340-6199
VL - 178
SP - 1033
EP - 1042
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 7
ER -