Increasing age at disability milestones among MS patients in the MSBase Registry

Ilya Kister; Eric Chamot; Gary Cutter; Tamar E. Bacon; Vilija G. Jokubaitis; Stella E Hughes; Orla M Gray; Maria Trojano; Guillermo Izquierdo; Francois Grand'Maison; Pierre Duquette; Alessandra Lugaresi; Pierre Grammond; Cavit Boz; Raymond Hupperts; Thor Petersen; Giorgio Giuliani; Celia Oreja-Guevara; Gerardo Iuliano; Jeannette Lechner-Scott; Roberto Bergamaschi; Maria Edite Rio; Freek Verheul; Marcela Fiol; Vincent Van Pesch; Mark Slee; Helmut Butzkueven; Joseph Herbert

doi:10.1016/j.jns.2012.03.017

Increasing age at disability milestones among MS patients in the MSBase Registry

Ilya Kister^*, Eric Chamot, Gary Cutter, Tamar E. Bacon, Vilija G. Jokubaitis, Stella E Hughes, Orla M Gray, Maria Trojano, Guillermo Izquierdo, Francois Grand'Maison, Pierre Duquette, Alessandra Lugaresi, Pierre Grammond, Cavit Boz, Raymond Hupperts, Thor Petersen, Giorgio Giuliani, Celia Oreja-Guevara, Gerardo Iuliano, Jeannette Lechner-ScottRoberto Bergamaschi, Maria Edite Rio, Freek Verheul, Marcela Fiol, Vincent Van Pesch, Mark Slee, Helmut Butzkueven, Joseph Herbert

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

30 Citations (Web of Science)

Abstract

To analyze time-trends in age at disability milestones among MS patients who were enrolled into the MSBase International Registry during 1996-2010 period.We used linear regression to describe the relationship between mean age at major EDSS benchmarks and calendar time. We then assessed time-trend in age at initial EDSS rating with a three level linear growth model specifying that patients were nested within each of 20 participating countries. The model estimated the average of time-trends in mean age at initial clinical assessment within each country while controlling for patients' EDSS and sex in each country. Analyses were repeated in subsamples of patients diagnosed according to Poser or McDonald criteria.The MSBase Registry contained data on 11,108 MS patients enrolled between 1996 and 2010 who fulfilled our inclusion criteria. During the 1996-2010 period, enrollment age for patients with EDSS 4/4.5 increased by 7.9 years, from 43 to 51 years (p

Original language	English
Pages (from-to)	94-99
Journal	Journal of the Neurological Sciences
Volume	318
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2012.03.017
Publication status	Published - 15 Jul 2012

Keywords

Multiple sclerosis
Epidemiology
Population-based registry

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10.1016/j.jns.2012.03.017

Cite this

Kister, I., Chamot, E., Cutter, G., Bacon, T. E., Jokubaitis, V. G., Hughes, S. E., Gray, O. M., Trojano, M., Izquierdo, G., Grand'Maison, F., Duquette, P., Lugaresi, A., Grammond, P., Boz, C., Hupperts, R., Petersen, T., Giuliani, G., Oreja-Guevara, C., Iuliano, G., ... Herbert, J. (2012). Increasing age at disability milestones among MS patients in the MSBase Registry. Journal of the Neurological Sciences, 318(1-2), 94-99. https://doi.org/10.1016/j.jns.2012.03.017

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title = "Increasing age at disability milestones among MS patients in the MSBase Registry",

abstract = "To analyze time-trends in age at disability milestones among MS patients who were enrolled into the MSBase International Registry during 1996-2010 period.We used linear regression to describe the relationship between mean age at major EDSS benchmarks and calendar time. We then assessed time-trend in age at initial EDSS rating with a three level linear growth model specifying that patients were nested within each of 20 participating countries. The model estimated the average of time-trends in mean age at initial clinical assessment within each country while controlling for patients' EDSS and sex in each country. Analyses were repeated in subsamples of patients diagnosed according to Poser or McDonald criteria.The MSBase Registry contained data on 11,108 MS patients enrolled between 1996 and 2010 who fulfilled our inclusion criteria. During the 1996-2010 period, enrollment age for patients with EDSS 4/4.5 increased by 7.9 years, from 43 to 51 years (p",

keywords = "Multiple sclerosis, Epidemiology, Population-based registry",

author = "Ilya Kister and Eric Chamot and Gary Cutter and Bacon, {Tamar E.} and Jokubaitis, {Vilija G.} and Hughes, {Stella E} and Gray, {Orla M} and Maria Trojano and Guillermo Izquierdo and Francois Grand'Maison and Pierre Duquette and Alessandra Lugaresi and Pierre Grammond and Cavit Boz and Raymond Hupperts and Thor Petersen and Giorgio Giuliani and Celia Oreja-Guevara and Gerardo Iuliano and Jeannette Lechner-Scott and Roberto Bergamaschi and Rio, {Maria Edite} and Freek Verheul and Marcela Fiol and {Van Pesch}, Vincent and Mark Slee and Helmut Butzkueven and Joseph Herbert",

year = "2012",

month = jul,

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doi = "10.1016/j.jns.2012.03.017",

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volume = "318",

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journal = "Journal of the Neurological Sciences",

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Kister, I, Chamot, E, Cutter, G, Bacon, TE, Jokubaitis, VG, Hughes, SE, Gray, OM, Trojano, M, Izquierdo, G, Grand'Maison, F, Duquette, P, Lugaresi, A, Grammond, P, Boz, C, Hupperts, R, Petersen, T, Giuliani, G, Oreja-Guevara, C, Iuliano, G, Lechner-Scott, J, Bergamaschi, R, Rio, ME, Verheul, F, Fiol, M, Van Pesch, V, Slee, M, Butzkueven, H & Herbert, J 2012, 'Increasing age at disability milestones among MS patients in the MSBase Registry', Journal of the Neurological Sciences, vol. 318, no. 1-2, pp. 94-99. https://doi.org/10.1016/j.jns.2012.03.017

TY - JOUR

T1 - Increasing age at disability milestones among MS patients in the MSBase Registry

AU - Kister, Ilya

AU - Chamot, Eric

AU - Cutter, Gary

AU - Bacon, Tamar E.

AU - Jokubaitis, Vilija G.

AU - Hughes, Stella E

AU - Gray, Orla M

AU - Trojano, Maria

AU - Izquierdo, Guillermo

AU - Grand'Maison, Francois

AU - Duquette, Pierre

AU - Lugaresi, Alessandra

AU - Grammond, Pierre

AU - Boz, Cavit

AU - Hupperts, Raymond

AU - Petersen, Thor

AU - Giuliani, Giorgio

AU - Oreja-Guevara, Celia

AU - Iuliano, Gerardo

AU - Lechner-Scott, Jeannette

AU - Bergamaschi, Roberto

AU - Rio, Maria Edite

AU - Verheul, Freek

AU - Fiol, Marcela

AU - Van Pesch, Vincent

AU - Slee, Mark

AU - Butzkueven, Helmut

AU - Herbert, Joseph

PY - 2012/7/15

Y1 - 2012/7/15

N2 - To analyze time-trends in age at disability milestones among MS patients who were enrolled into the MSBase International Registry during 1996-2010 period.We used linear regression to describe the relationship between mean age at major EDSS benchmarks and calendar time. We then assessed time-trend in age at initial EDSS rating with a three level linear growth model specifying that patients were nested within each of 20 participating countries. The model estimated the average of time-trends in mean age at initial clinical assessment within each country while controlling for patients' EDSS and sex in each country. Analyses were repeated in subsamples of patients diagnosed according to Poser or McDonald criteria.The MSBase Registry contained data on 11,108 MS patients enrolled between 1996 and 2010 who fulfilled our inclusion criteria. During the 1996-2010 period, enrollment age for patients with EDSS 4/4.5 increased by 7.9 years, from 43 to 51 years (p

AB - To analyze time-trends in age at disability milestones among MS patients who were enrolled into the MSBase International Registry during 1996-2010 period.We used linear regression to describe the relationship between mean age at major EDSS benchmarks and calendar time. We then assessed time-trend in age at initial EDSS rating with a three level linear growth model specifying that patients were nested within each of 20 participating countries. The model estimated the average of time-trends in mean age at initial clinical assessment within each country while controlling for patients' EDSS and sex in each country. Analyses were repeated in subsamples of patients diagnosed according to Poser or McDonald criteria.The MSBase Registry contained data on 11,108 MS patients enrolled between 1996 and 2010 who fulfilled our inclusion criteria. During the 1996-2010 period, enrollment age for patients with EDSS 4/4.5 increased by 7.9 years, from 43 to 51 years (p

KW - Multiple sclerosis

KW - Epidemiology

KW - Population-based registry

U2 - 10.1016/j.jns.2012.03.017

DO - 10.1016/j.jns.2012.03.017

M3 - Article

C2 - 22507751

SN - 0022-510X

VL - 318

SP - 94

EP - 99

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 1-2

ER -