Abstract
Survival of expanded criteria donor (ECD) kidneys and their recipients has not been thoroughly evaluated in Europe. Therefore, we compared the outcome of ECD and non-ECD kidney transplantations in a Dutch cohort, stratifying by age and diabetes. In all first Dutch kidney transplants in recipients >= 18 years between 1995 and 2005, both relative risks (hazard ratios, HR) and adjusted absolute risk differences (RD) for ECD kidney transplantation were analysed. In 3062 transplantations [recipient age 49.0 (12.8) years; 20% ECD], ECD kidney transplantation was associated with graft failure including death [HR 1.62 (1.44-1.82)]. The adjusted HR was lower in recipients >= 60 years of age [1.32 (1.07-1.63)] than in recipients 40-59 years [1.71 (1.44-2.02) P = 0.12 for comparison with >= 60 years] and recipients 18-39 years [1.92 (1.42-2.62) P = 0.03 for comparison with >= 60 years]. RDs showed a similar pattern. In diabetics, the risks for graft failure and death were higher than in the nondiabetics. ECD kidney grafts have a poorer prognosis than non-ECD grafts, especially in younger recipients (
Original language | English |
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Pages (from-to) | 14-28 |
Number of pages | 15 |
Journal | Transplant International |
Volume | 30 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2017 |
Keywords
- donation after brain death
- donation after cardiac death
- expanded criteria donor
- graft survival
- kidney transplantation
- patient survival
- RENAL-TRANSPLANTATION
- MULTIPLE IMPUTATION
- SCORING SYSTEM
- SURVIVAL
- OUTCOMES
- QUALITY
- METAANALYSIS
- PROVIDE
- MODEL
- POOL