Increased neural activation during picture encoding and retrieval in 60-year-olds compared to 20-year-olds.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Brain aging has been associated with both reduced and increased neural activity during task execution. The purpose of the present study was to investigate whether increased neural activation during memory encoding and retrieval is already present at the age of 60 as well as to obtain more insight into the mechanism behind increased activity. Eighteen young (mean age 21.3) and 18 older (mean age 59.9) right-handed male participants were administered two picture memory tasks in an fMRI environment. Neural activation was measured during encoding and retrieval of pictures of natural scenes (landscapes) and physical objects. Results indicated reduced medial temporal activity during encoding in older participants and increased activity during both encoding and retrieval in several other areas in the brain, including the inferior and dorsolateral prefrontal cortices. This increased activation was not related to better memory performance. The present findings indicate that increased neural activation during memory tasks is present in individuals near the age of 60 compared to individuals near the age of 20, which extends findings from studies of more-advanced age groups. Also, increased activation was present even though cognitive performance at 60 was not as impaired as is generally found in more-advanced age groups. Although compensation is a plausible explanation of the increased activation at this age, we suggest that other mechanisms like disinhibition, dedifferentiation, or the recruitment of less-efficient cognitive strategies may be more likely. 

Original languageEnglish
Pages (from-to)2188-2197
Number of pages10
JournalNeuropsychologia
Volume48
Issue number7
DOIs
Publication statusPublished - Jun 2010

Keywords

  • AGING MIND
  • ALZHEIMERS-DISEASE
  • Aging
  • BRAIN ACTIVITY
  • Frontal lobe
  • HEMISPHERIC-SPECIALIZATION
  • MEDIAL TEMPORAL-LOBE
  • MILD COGNITIVE IMPAIRMENT
  • Medial temporal lobe
  • Memory
  • NORMATIVE DATA
  • OLD ADULTS
  • PARTICIPANTS AGED 24-81
  • WORKING-MEMORY
  • compensation
  • fMRI

Cite this

@article{891826d3020f4855a6936dbf19773683,
title = "Increased neural activation during picture encoding and retrieval in 60-year-olds compared to 20-year-olds.",
abstract = "Brain aging has been associated with both reduced and increased neural activity during task execution. The purpose of the present study was to investigate whether increased neural activation during memory encoding and retrieval is already present at the age of 60 as well as to obtain more insight into the mechanism behind increased activity. Eighteen young (mean age 21.3) and 18 older (mean age 59.9) right-handed male participants were administered two picture memory tasks in an fMRI environment. Neural activation was measured during encoding and retrieval of pictures of natural scenes (landscapes) and physical objects. Results indicated reduced medial temporal activity during encoding in older participants and increased activity during both encoding and retrieval in several other areas in the brain, including the inferior and dorsolateral prefrontal cortices. This increased activation was not related to better memory performance. The present findings indicate that increased neural activation during memory tasks is present in individuals near the age of 60 compared to individuals near the age of 20, which extends findings from studies of more-advanced age groups. Also, increased activation was present even though cognitive performance at 60 was not as impaired as is generally found in more-advanced age groups. Although compensation is a plausible explanation of the increased activation at this age, we suggest that other mechanisms like disinhibition, dedifferentiation, or the recruitment of less-efficient cognitive strategies may be more likely. ",
keywords = "AGING MIND, ALZHEIMERS-DISEASE, Aging, BRAIN ACTIVITY, Frontal lobe, HEMISPHERIC-SPECIALIZATION, MEDIAL TEMPORAL-LOBE, MILD COGNITIVE IMPAIRMENT, Medial temporal lobe, Memory, NORMATIVE DATA, OLD ADULTS, PARTICIPANTS AGED 24-81, WORKING-MEMORY, compensation, fMRI",
author = "S. Burgmans and {van Boxtel}, M.P.J. and E.F.P.M. Vuurman and E.A.T. Evers and J. Jolles",
year = "2010",
month = "6",
doi = "10.1016/j.neuropsychologia.2010.04.011",
language = "English",
volume = "48",
pages = "2188--2197",
journal = "Neuropsychologia",
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Increased neural activation during picture encoding and retrieval in 60-year-olds compared to 20-year-olds. / Burgmans, S.; van Boxtel, M.P.J.; Vuurman, E.F.P.M.; Evers, E.A.T.; Jolles, J.

In: Neuropsychologia, Vol. 48, No. 7, 06.2010, p. 2188-2197.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Increased neural activation during picture encoding and retrieval in 60-year-olds compared to 20-year-olds.

AU - Burgmans, S.

AU - van Boxtel, M.P.J.

AU - Vuurman, E.F.P.M.

AU - Evers, E.A.T.

AU - Jolles, J.

PY - 2010/6

Y1 - 2010/6

N2 - Brain aging has been associated with both reduced and increased neural activity during task execution. The purpose of the present study was to investigate whether increased neural activation during memory encoding and retrieval is already present at the age of 60 as well as to obtain more insight into the mechanism behind increased activity. Eighteen young (mean age 21.3) and 18 older (mean age 59.9) right-handed male participants were administered two picture memory tasks in an fMRI environment. Neural activation was measured during encoding and retrieval of pictures of natural scenes (landscapes) and physical objects. Results indicated reduced medial temporal activity during encoding in older participants and increased activity during both encoding and retrieval in several other areas in the brain, including the inferior and dorsolateral prefrontal cortices. This increased activation was not related to better memory performance. The present findings indicate that increased neural activation during memory tasks is present in individuals near the age of 60 compared to individuals near the age of 20, which extends findings from studies of more-advanced age groups. Also, increased activation was present even though cognitive performance at 60 was not as impaired as is generally found in more-advanced age groups. Although compensation is a plausible explanation of the increased activation at this age, we suggest that other mechanisms like disinhibition, dedifferentiation, or the recruitment of less-efficient cognitive strategies may be more likely. 

AB - Brain aging has been associated with both reduced and increased neural activity during task execution. The purpose of the present study was to investigate whether increased neural activation during memory encoding and retrieval is already present at the age of 60 as well as to obtain more insight into the mechanism behind increased activity. Eighteen young (mean age 21.3) and 18 older (mean age 59.9) right-handed male participants were administered two picture memory tasks in an fMRI environment. Neural activation was measured during encoding and retrieval of pictures of natural scenes (landscapes) and physical objects. Results indicated reduced medial temporal activity during encoding in older participants and increased activity during both encoding and retrieval in several other areas in the brain, including the inferior and dorsolateral prefrontal cortices. This increased activation was not related to better memory performance. The present findings indicate that increased neural activation during memory tasks is present in individuals near the age of 60 compared to individuals near the age of 20, which extends findings from studies of more-advanced age groups. Also, increased activation was present even though cognitive performance at 60 was not as impaired as is generally found in more-advanced age groups. Although compensation is a plausible explanation of the increased activation at this age, we suggest that other mechanisms like disinhibition, dedifferentiation, or the recruitment of less-efficient cognitive strategies may be more likely. 

KW - AGING MIND

KW - ALZHEIMERS-DISEASE

KW - Aging

KW - BRAIN ACTIVITY

KW - Frontal lobe

KW - HEMISPHERIC-SPECIALIZATION

KW - MEDIAL TEMPORAL-LOBE

KW - MILD COGNITIVE IMPAIRMENT

KW - Medial temporal lobe

KW - Memory

KW - NORMATIVE DATA

KW - OLD ADULTS

KW - PARTICIPANTS AGED 24-81

KW - WORKING-MEMORY

KW - compensation

KW - fMRI

U2 - 10.1016/j.neuropsychologia.2010.04.011

DO - 10.1016/j.neuropsychologia.2010.04.011

M3 - Article

VL - 48

SP - 2188

EP - 2197

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 7

ER -