Increased Mortality Among Patients With vs Without Cirrhosis and Autoimmune Hepatitis

F.F. van den Brand, K.S. van der Veen, Y.S. de Boer, N.M. van Gerven, B.I. Lissenberg-Witte, U. Beuers, K.J. van Erpecum, H.R. van Buuren, J.W. den Ouden, J.T. Brouwer, J.M. Vrolijk, R.C. Verdonk, B. van Hoek, G.H. Koek, J.P.H. Drenth, M.M.J. Guichelaar, C.J.J. Mulder, E. Bloemena, C.M.J. van Nieuwkerk, G. Bouma*Dutch Autoimmune Hepatitis Study Group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND & AIMS: There have been few reproducible studies of mortality in patients with autoimmune hepatitis (AIH) and its variants. We calculated mortality in a large national cohort of patients with AIH, with vs without cirrhosis, in the Netherlands.METHODS: We collected data from 449 patients with established AIH (77% female), from 6 academic and 10 non-academic hospitals in the Netherlands. We identified 29 patients with AIH and primary biliary cholangitis and 35 patients with AIH and primary sclerosing cholangitis (AIH-PSC). Mortality and liver transplantation data were assessed from August 1, 2006 through July 31, 2016. Standardized mortality ratios (SMR) were calculated using age-, sex-, and calendar year-matched mortality for the general Dutch population.RESULTS: During the 10-year follow-up period, 60 patients (13%) died (mean age, 71 years; range, 33-94 years). Twenty-six causes of death were liver related (43%), whereas the others could not be attributed to liver disease. Patients with AIH and cirrhosis had significantly higher mortality than the general population (SMR, 1.9; 95% CI, 1.2-3.4), whereas patients without cirrhosis did not (SMR, 1.2; 95% CI, 0.8-1.8). Patients with AIH-PSC had the largest increase in mortality, compared to the general population (SMR, 4.7; 95% CI, 1.5-14.6), of all groups analyzed. Mortality in patients with AIH and primary biliary cholangitis was not greater than the general population. Four or more relapses per decade or not achieving remission was associated with an increase in liver-related death or liver transplantation. Nine patients underwent liver transplantation; 2 died from non-liver related causes. Four of 9 patients on the waitlist for transplantation died before receiving a donated liver.CONCLUSION: In an analysis of data from a large national cohort of patients with AIH, we found increased mortality of patients with cirrhosis, but not of patients without cirrhosis, compared to the general Dutch population. Survival was significantly reduced in patients with AIH and features of concurrent PSC.
Original languageEnglish
Pages (from-to)940-947.e2
Number of pages10
JournalClinical gastroenterology and hepatology
Issue number5
Publication statusPublished - 1 Apr 2019


  • autoimmune liver disease
  • clinical-features
  • diagnosis
  • long term
  • management
  • natural-history
  • outcome
  • prognosis
  • relapse
  • remission
  • withdrawal
  • Relapse
  • Autoimmune Liver Disease
  • Outcome
  • Remission
  • Long Term


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