Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

Jian Jiang, Jacob J. Briede, Danyel G. J. Jennen, Anke Van Summeren, Karen Saritas-Brauers, Gert Schaart, Jos C. S. Kleinjans, Theo M. C. M. de Kok

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
Original languageEnglish
Pages (from-to)139-150
JournalToxicology Letters
Volume234
Issue number2
DOIs
Publication statusPublished - 16 Apr 2015

Keywords

  • Toxicogenomics
  • Acetaminophen
  • HepG2
  • Microarray
  • ESR
  • Mitochondrial ROS

Cite this

@article{579fde70f0af407d82f14fa50b64a390,
title = "Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain",
keywords = "Toxicogenomics, Acetaminophen, HepG2, Microarray, ESR, Mitochondrial ROS",
author = "Jian Jiang and Briede, {Jacob J.} and Jennen, {Danyel G. J.} and {Van Summeren}, Anke and Karen Saritas-Brauers and Gert Schaart and Kleinjans, {Jos C. S.} and {de Kok}, {Theo M. C. M.}",
year = "2015",
month = "4",
day = "16",
doi = "10.1016/j.toxlet.2015.02.012",
language = "English",
volume = "234",
pages = "139--150",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. / Jiang, Jian; Briede, Jacob J.; Jennen, Danyel G. J.; Van Summeren, Anke; Saritas-Brauers, Karen; Schaart, Gert; Kleinjans, Jos C. S.; de Kok, Theo M. C. M.

In: Toxicology Letters, Vol. 234, No. 2, 16.04.2015, p. 139-150.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

AU - Jiang, Jian

AU - Briede, Jacob J.

AU - Jennen, Danyel G. J.

AU - Van Summeren, Anke

AU - Saritas-Brauers, Karen

AU - Schaart, Gert

AU - Kleinjans, Jos C. S.

AU - de Kok, Theo M. C. M.

PY - 2015/4/16

Y1 - 2015/4/16

KW - Toxicogenomics

KW - Acetaminophen

KW - HepG2

KW - Microarray

KW - ESR

KW - Mitochondrial ROS

U2 - 10.1016/j.toxlet.2015.02.012

DO - 10.1016/j.toxlet.2015.02.012

M3 - Article

VL - 234

SP - 139

EP - 150

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 2

ER -