Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks

A. Fucic*, J. Katic, E. Fthenou, M. Kogevinas, D. Plavec, J. Koppe, D. Batinic, G. Chalkiadaki, L. Chatzi, R. Lasan, J. Kleinjans, M. Kirsch-Volders

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with = 2 MNMONO/1000 than in newborns with
Original languageEnglish
Pages (from-to)110-115
JournalReproductive Toxicology
Volume42
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Newborn
  • Micronucleus assay
  • Binuclear lymphocyte
  • Mononuclear lymphocyte
  • Mother
  • Nuclear division index
  • C-FISH

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