Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks

A. Fucic; J. Katic; E. Fthenou; M. Kogevinas; D. Plavec; J. Koppe; D. Batinic; G. Chalkiadaki; L. Chatzi; R. Lasan; J. Kleinjans; M. Kirsch-Volders

doi:10.1016/j.reprotox.2013.08.004

Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks

A. Fucic^*, J. Katic, E. Fthenou, M. Kogevinas, D. Plavec, J. Koppe, D. Batinic, G. Chalkiadaki, L. Chatzi, R. Lasan, J. Kleinjans, M. Kirsch-Volders

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with = 2 MNMONO/1000 than in newborns with

Original language	English
Pages (from-to)	110-115
Journal	Reproductive Toxicology
Volume	42
DOIs	https://doi.org/10.1016/j.reprotox.2013.08.004
Publication status	Published - Dec 2013

Keywords

Newborn
Micronucleus assay
Binuclear lymphocyte
Mononuclear lymphocyte
Mother
Nuclear division index
C-FISH

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10.1016/j.reprotox.2013.08.004

Cite this

Fucic, A., Katic, J., Fthenou, E., Kogevinas, M., Plavec, D., Koppe, J., Batinic, D., Chalkiadaki, G., Chatzi, L., Lasan, R., Kleinjans, J., & Kirsch-Volders, M. (2013). Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks. Reproductive Toxicology, 42, 110-115. https://doi.org/10.1016/j.reprotox.2013.08.004

@article{32aff1591c944f8c9292cc8a38d8b0c0,

title = "Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks",

abstract = "Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with = 2 MNMONO/1000 than in newborns with ",

keywords = "Newborn, Micronucleus assay, Binuclear lymphocyte, Mononuclear lymphocyte, Mother, Nuclear division index, C-FISH",

author = "A. Fucic and J. Katic and E. Fthenou and M. Kogevinas and D. Plavec and J. Koppe and D. Batinic and G. Chalkiadaki and L. Chatzi and R. Lasan and J. Kleinjans and M. Kirsch-Volders",

year = "2013",

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doi = "10.1016/j.reprotox.2013.08.004",

language = "English",

volume = "42",

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journal = "Reproductive Toxicology",

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Fucic, A, Katic, J, Fthenou, E, Kogevinas, M, Plavec, D, Koppe, J, Batinic, D, Chalkiadaki, G, Chatzi, L, Lasan, R, Kleinjans, J & Kirsch-Volders, M 2013, 'Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks', Reproductive Toxicology, vol. 42, pp. 110-115. https://doi.org/10.1016/j.reprotox.2013.08.004

TY - JOUR

T1 - Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks

AU - Fucic, A.

AU - Katic, J.

AU - Fthenou, E.

AU - Kogevinas, M.

AU - Plavec, D.

AU - Koppe, J.

AU - Batinic, D.

AU - Chalkiadaki, G.

AU - Chatzi, L.

AU - Lasan, R.

AU - Kleinjans, J.

AU - Kirsch-Volders, M.

PY - 2013/12

Y1 - 2013/12

N2 - Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with = 2 MNMONO/1000 than in newborns with

AB - Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with = 2 MNMONO/1000 than in newborns with

KW - Newborn

KW - Micronucleus assay

KW - Binuclear lymphocyte

KW - Mononuclear lymphocyte

KW - Mother

KW - Nuclear division index

KW - C-FISH

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DO - 10.1016/j.reprotox.2013.08.004

M3 - Article

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SN - 0890-6238

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