Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B

Michel van Weeghel, Desiree Abdurrachim, Rianne Nederlof, Carmen A. Argmann, Riekelt H. Houtkooper, Jacob Hagen, Miranda Nabben, Simone Denis, Jolita Ciapaite, Stephen C. Kolwicz, Gary D. Lopaschuk, Johan Auwerx, Klaas Nicolay, Christine Des Rosiers, Ronald J. Wanders, Coert J. Zuurbier, Jeanine J. Prompers, Sander M. Houten

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1324-1334
Number of pages11
JournalCardiovascular Research
Volume114
Issue number10
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Malonyl-CoA
  • Allosteric regulation of enzyme activity
  • Glucose-fatty acid cycle
  • Heart metabolism
  • Carnitine palmitoyltransferase
  • CARNITINE PALMITOYLTRANSFERASE-I
  • COENZYME-A DECARBOXYLASE
  • MALONYL-COA
  • PRESSURE-OVERLOAD
  • BETA-OXIDATION
  • GLUCOSE-OXIDATION
  • KNOCKOUT MICE
  • RAT-LIVER
  • HEART
  • DEFICIENCY

Cite this

van Weeghel, M., Abdurrachim, D., Nederlof, R., Argmann, C. A., Houtkooper, R. H., Hagen, J., Nabben, M., Denis, S., Ciapaite, J., Kolwicz, S. C., Lopaschuk, G. D., Auwerx, J., Nicolay, K., Des Rosiers, C., Wanders, R. J., Zuurbier, C. J., Prompers, J. J., & Houten, S. M. (2018). Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B. Cardiovascular Research, 114(10), 1324-1334. https://doi.org/10.1093/cvr/cvy089