@article{294e4fc3b82746ba94985dc78f9b234d,
title = "Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain",
abstract = "The subventricular zone (SVZ) is a site of neurogenesis in the aging brain, and epigenetic mechanisms have been implicated in regulating the {"}normal{"} distribution of new nerve cells into the existing cellular milieu. In a case-control study of human primary SVZ cultures and fixed tissue from the same individuals, we have found significant increases in DNA hydroxymethylation levels in the SVZ of Alzheimer's disease patients compared with nondiseased control subjects. We show that this increase in hydroxymethylation directly correlates to an increase in cellular proliferation in Alzheimer's disease precursor cells, which implicates the hydroxymethylation tag to a higher degree of cellular proliferation.",
author = "Diego Mastroeni and Leonidas Chouliaras and \{Van den Hove\}, \{Daniel L.\} and Jennifer Nolz and Rutten, \{Bart P.F.\} and Elaine Delvaux and Coleman, \{Paul D.\}",
note = "Funding Information: The authors declare no competing financial or conflict of interests. We are grateful to the Banner Sun Health Research Institute Brain and Body Donation Program of Sun City, AZ, for the provision of human brain samples. The Brain and Body Donation Program is supported by the National Institute of Neurological Disorders and Stroke ( U24 NS072026 National Brain and Tissue Resource for Parkinson's Disease and Related Disorders), the National Institute on Aging ( P30 AG19610 Arizona Alzheimer's Disease Core Center), the Arizona Department of Health Services (contract 211002 , Arizona Alzheimer's Research Center), the Arizona Biomedical Research Commission (contracts 4001 , 0011 , 05-901 , and 1001 to the Arizona Parkinson's Disease Consortium), and the Michael J. Fox Foundation for Parkinson's Research . This work was supported by NIRG - 14-321390 and ADHS 14-080000 FY2015 to DM. Publisher Copyright: {\textcopyright} 2016 The Authors.",
year = "2016",
month = jun,
day = "1",
doi = "10.1016/j.nepig.2016.04.002",
language = "English",
volume = "6",
pages = "26--31",
journal = "Neuroepigenetics",
issn = "2214-7845",
publisher = "Elsevier B.V.",
}