Increase of prevalence of craniosynostosis

Martijn Cornelissen*, Bianca den Ottelander, Dimitris Rizopoulos, Rene van der Hulst, Aebele Mink van der Molen, Chantal van der Horst, Hans Delye, Marie-Lise van Veelen, Gouke Bonsel, Irene Mathijssen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

90 Citations (Web of Science)

Abstract

Introduction: Craniosynostosis represents premature closure of cranial sutures. Prevalence is approximately 3.1-6.4 in 10.000 live births, which is reportedly rising. This epidemiologic study aims to provide insight into this rise through an accurate description of the prevalence, exploring regional variation and change over time. Methods: The Dutch Association for Cleft Palate and Craniofacial Anomalies was consulted to identify patients with craniosynostosis born between 2008 and 2013. Data were verified using data provided by all hospitals that treated these patients. The following data were collected: date of birth, gender, diagnosis and postal code. Previously reported data from 1997 until 2007 were included to assess for change in prevalence over the years. Results: Between 2008 and 2013 759 patients with craniosynostosis were born in the Netherlands. Prevalence of craniosynostosis was 7.2 per 10.000 live births. Sagittal synostosis was the most common form (44%). Poisson regression analysis showed a significant mean annual increase of prevalence of total craniosynostosis (+12.5%), sagittal (+11.7%) and metopic (+20.5%) synostosis from 1997 to 2013. Conclusion: The prevalence of craniosynostosis is 7.2 per 10.000 live born children in the Netherlands. Prevalence of total craniosynostosis, sagittal and metopic suture synostosis has risen significantly from 1997 until 2013, without obvious cause.
Original languageEnglish
Pages (from-to)1273-1279
JournalJournal of Cranio-Maxillofacial Surgery
Volume44
Issue number9
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Craniosynostosis
  • Prevalence
  • Craniofacial
  • Birth defect

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