Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies against the Thrombin-Sensitive Region of Murine Protein S

Pieter Van de Vijver*, Martin Schmitt, Dennis Suylen, Liesbeth Scheer, M. Christella L. G. D. Thomassen, Leon J. Schurgers, John H. Griffin, Rory R. Koenen, Tilman M. Hackeng

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Antigenic peptide:. conjugates can be used as vaccines and for the production of antibodies for clinical and research use A method is presented here for the construction of conjugates incorporating oxidatively folded protein domains in their native conformation. This method was used to prepare multiple antigenic peptide constructs of the thrombin sensitive loop region of murine anticoagulant protein S.
Original languageEnglish
Pages (from-to)19318-19321
JournalJournal of the American Chemical Society
Volume134
Issue number47
DOIs
Publication statusPublished - 28 Nov 2012

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