Abstract
Purpose: To evaluate whether inclusion of incidental radiation dose to the cardiac atria and ventricles improves the prediction of grade >= 3 radiation pneumonitis (RP) in advanced-stage non-small cell lung cancer (AS-NSCLC) patients treated with intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT).
Methods and Materials: Using a bootstrap modeling approach, clinical parameters and doseevolume histogram (DVH) parameters of lungs and heart (assessing atria and ventricles separately and combined) were evaluated for RP prediction in 188 AS-NSCLC patients.
Results: After a median follow-up of 18.4 months, 26 patients (13.8%) developed RP. Only the median mean lung dose (MLD) differed between groups (15.3 Gy vs 13.7 Gy for the RP and non-RP group, respectively; P=.004). The MLD showed the highest Spearman correlation coefficient (Rs) for RP (Rs = 0.21; P= 3 RP, whereas the heart DVH parameters were seldom included in the model.
Conclusion: Incidental dose to the cardiac atria and ventricles did not improve RP risk prediction in our cohort of 188 AS-NSCLC patients treated with IMRT or VMAT. (C) 2017 Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 434-441 |
Number of pages | 8 |
Journal | International Journal of Radiation Oncology Biology Physics |
Volume | 99 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Oct 2017 |
Keywords
- HEART IRRADIATION
- RISK-FACTOR
- RADIOTHERAPY
- VOLUME
- TOXICITY
- METAANALYSIS
- EXPOSURE
- IMPACT
- ATLAS