Abstract
aSummaryWe studied the incidence of subsequent fractures in persons of 50+years from 1990 to 2012 and the relative risk (RR) of subsequent fractures after an index femur/hip fracture, stratified per 5-year age band. Patients suffering a fracture have a high incidence of a subsequent fracture; the RR of subsequent fracture after a femur/hip fracture ranged from 2 to 7.IntroductionRecent information on the risk of subsequent fractures after a broad range of index fractures in the UK population is scarce. We therefore studied the rates of subsequent fractures of the femur/hip, humerus, radius/ulna, vertebrae, rib, or pelvis after fractures at one of these sites from 1990 to 2012 in 3,156,347 UK men and women aged 50years or over.MethodsWe undertook a retrospective observational study using the UK Clinical Practice Research Datalink (CPRD). The incidence of subsequent fractures at a specific site was calculated by dividing the observed number of fractures by the number of person-years (py) at risk. The relative risk (RR) of subsequent fractures after a femur/hip fracture, by 5-year age band, was calculated by dividing the incidence of a specific subsequent fracture type by the incidence of first fractures at the same site in the same age group.ResultsThe highest subsequent fracture incidence after a femur/hip fracture was for humerus fracture in men (59.5/10.000py) and radius/ulna fracture in women (117.2/10.000py). After an index fracture of the radius/ulna, humerus fracture in men (59.3/10.000py) and femur/hip fracture in women (82.4 per 10.000py) were most frequent. The RR of fractures after a femur/hip fracture ranged from 2 to 7 and were highest in men and younger age groups.ConclusionPatients suffering a fracture have a high incidence of a subsequent fracture. Our findings demonstrate the importance of fracture prevention in patients with a history of a fracture by adequate medical diagnosis and treatment.
Original language | English |
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Pages (from-to) | 2469-2475 |
Number of pages | 7 |
Journal | Osteoporosis International |
Volume | 29 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2018 |
Keywords
- Epidemiology
- Fracture incidence
- Osteoporosis
- Subsequent fractures
- PRACTICE RESEARCH DATABASE
- POPULATION-BASED COHORT
- HIP FRACTURE
- FRAGILITY FRACTURES
- OSTEOPOROTIC FRACTURES
- VERTEBRAL FRACTURE
- ELDERLY-WOMEN
- DATA RESOURCE
- PRIMARY-CARE
- RISK
- Recurrence
- Age Distribution
- Humans
- Middle Aged
- Male
- Femoral Fractures/epidemiology
- Incidence
- Female
- Retrospective Studies
- Risk Assessment/methods
- Osteoporotic Fractures/epidemiology
- Databases, Factual
- United Kingdom/epidemiology
- Hip Fractures/epidemiology
- Aged