Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Jasmijn F. Haanstra; Abdul Al-Toma; Evelien Dekker; Steven A. L. W. Vanhoutvin; Fokko M. Nagengast; Elisabeth M. Mathus-Vliegen; Monique E. van Leerdam; Wouter H. de Vos Tot Nederveen Cappel; Roeland A. Veenendaal; Annemieke Cats; Silvia Sanduleanu; Hans F. A. Vasen; Jan H. Kleibeuker; Jan J. Koornstra

doi:10.1055/s-0043-111723

Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Jasmijn F. Haanstra, Abdul Al-Toma, Evelien Dekker, Steven A. L. W. Vanhoutvin, Fokko M. Nagengast, Elisabeth M. Mathus-Vliegen, Monique E. van Leerdam, Wouter H. de Vos Tot Nederveen Cappel, Roeland A. Veenendaal, Annemieke Cats, Silvia Sanduleanu, Hans F. A. Vasen, Jan H. Kleibeuker, Jan J. Koornstra^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Web of Science)

Abstract

Background and study aims Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre) malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by video capsule endoscopy (VCE). The aim of this prospective study was to determine the incidence of SBN.

Patients and methods Asymptomatic LS patients who underwent a VCE were invited to undergo a second VCE procedure 2 years later. If abnormalities or polypoid lesions larger than 1 cm were detected, subsequent endoscopic procedures were performed.

Results A total of 155 (78%) of the initial 200 patients underwent a second VCE procedure after a mean of 2.2 (range 1 - 6) years. In 17 of the 155 (11%) patients possibly significant lesions were detected, which required further investigation by means of gastroduodenoscopy (n = 8) or balloon-assisted endoscopy (n = 9). These procedures revealed no SBN.

Conclusion No SBN was found after 2 years. Surveillance of the small bowel by VCE does not seem to be warranted in asymptomatic LS patients.

Original language	English
Pages (from-to)	E622-E626
Number of pages	5
Journal	Endoscopy international open
Volume	5
Issue number	7
DOIs	https://doi.org/10.1055/s-0043-111723
Publication status	Published - Jul 2017

Keywords

CANCER

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10.1055/s-0043-111723

Cite this

Haanstra, J. F., Al-Toma, A., Dekker, E., Vanhoutvin, S. A. L. W., Nagengast, F. M., Mathus-Vliegen, E. M., van Leerdam, M. E., Cappel, W. H. D. V. T. N., Veenendaal, R. A., Cats, A., Sanduleanu, S., Vasen, H. F. A., Kleibeuker, J. H., & Koornstra, J. J. (2017). Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy. Endoscopy international open, 5(7), E622-E626. https://doi.org/10.1055/s-0043-111723

@article{da75256bbbe44dfbb41fc55f03616e1f,

title = "Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy",

abstract = "Background and study aims Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre) malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by video capsule endoscopy (VCE). The aim of this prospective study was to determine the incidence of SBN.Patients and methods Asymptomatic LS patients who underwent a VCE were invited to undergo a second VCE procedure 2 years later. If abnormalities or polypoid lesions larger than 1 cm were detected, subsequent endoscopic procedures were performed.Results A total of 155 (78%) of the initial 200 patients underwent a second VCE procedure after a mean of 2.2 (range 1 - 6) years. In 17 of the 155 (11%) patients possibly significant lesions were detected, which required further investigation by means of gastroduodenoscopy (n = 8) or balloon-assisted endoscopy (n = 9). These procedures revealed no SBN.Conclusion No SBN was found after 2 years. Surveillance of the small bowel by VCE does not seem to be warranted in asymptomatic LS patients.",

keywords = "CANCER",

author = "Haanstra, {Jasmijn F.} and Abdul Al-Toma and Evelien Dekker and Vanhoutvin, {Steven A. L. W.} and Nagengast, {Fokko M.} and Mathus-Vliegen, {Elisabeth M.} and {van Leerdam}, {Monique E.} and Cappel, {Wouter H. de Vos Tot Nederveen} and Veenendaal, {Roeland A.} and Annemieke Cats and Silvia Sanduleanu and Vasen, {Hans F. A.} and Kleibeuker, {Jan H.} and Koornstra, {Jan J.}",

year = "2017",

month = jul,

doi = "10.1055/s-0043-111723",

language = "English",

volume = "5",

pages = "E622--E626",

journal = "Endoscopy international open",

issn = "2364-3722",

publisher = "Georg Thieme Verlag",

number = "7",

}

Haanstra, JF, Al-Toma, A, Dekker, E, Vanhoutvin, SALW, Nagengast, FM, Mathus-Vliegen, EM, van Leerdam, ME, Cappel, WHDVTN, Veenendaal, RA, Cats, A, Sanduleanu, S, Vasen, HFA, Kleibeuker, JH & Koornstra, JJ 2017, 'Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy', Endoscopy international open, vol. 5, no. 7, pp. E622-E626. https://doi.org/10.1055/s-0043-111723

TY - JOUR

T1 - Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

AU - Haanstra, Jasmijn F.

AU - Al-Toma, Abdul

AU - Dekker, Evelien

AU - Vanhoutvin, Steven A. L. W.

AU - Nagengast, Fokko M.

AU - Mathus-Vliegen, Elisabeth M.

AU - van Leerdam, Monique E.

AU - Cappel, Wouter H. de Vos Tot Nederveen

AU - Veenendaal, Roeland A.

AU - Cats, Annemieke

AU - Sanduleanu, Silvia

AU - Vasen, Hans F. A.

AU - Kleibeuker, Jan H.

AU - Koornstra, Jan J.

PY - 2017/7

Y1 - 2017/7

N2 - Background and study aims Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre) malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by video capsule endoscopy (VCE). The aim of this prospective study was to determine the incidence of SBN.Patients and methods Asymptomatic LS patients who underwent a VCE were invited to undergo a second VCE procedure 2 years later. If abnormalities or polypoid lesions larger than 1 cm were detected, subsequent endoscopic procedures were performed.Results A total of 155 (78%) of the initial 200 patients underwent a second VCE procedure after a mean of 2.2 (range 1 - 6) years. In 17 of the 155 (11%) patients possibly significant lesions were detected, which required further investigation by means of gastroduodenoscopy (n = 8) or balloon-assisted endoscopy (n = 9). These procedures revealed no SBN.Conclusion No SBN was found after 2 years. Surveillance of the small bowel by VCE does not seem to be warranted in asymptomatic LS patients.

AB - Background and study aims Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre) malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by video capsule endoscopy (VCE). The aim of this prospective study was to determine the incidence of SBN.Patients and methods Asymptomatic LS patients who underwent a VCE were invited to undergo a second VCE procedure 2 years later. If abnormalities or polypoid lesions larger than 1 cm were detected, subsequent endoscopic procedures were performed.Results A total of 155 (78%) of the initial 200 patients underwent a second VCE procedure after a mean of 2.2 (range 1 - 6) years. In 17 of the 155 (11%) patients possibly significant lesions were detected, which required further investigation by means of gastroduodenoscopy (n = 8) or balloon-assisted endoscopy (n = 9). These procedures revealed no SBN.Conclusion No SBN was found after 2 years. Surveillance of the small bowel by VCE does not seem to be warranted in asymptomatic LS patients.

KW - CANCER

U2 - 10.1055/s-0043-111723

DO - 10.1055/s-0043-111723

M3 - Article

C2 - 28691043

VL - 5

SP - E622-E626

JO - Endoscopy international open

JF - Endoscopy international open

SN - 2364-3722

IS - 7

ER -