Incidence of Oral Anticoagulant-Associated Intracerebral Hemorrhage in the Netherlands

Angel M. R. Schols; Floris H. B. M. Schreuder; Elisabeth P. M. van Raak; Tobien H. C. M. L. Schreuder; Fergus A. Rooyer; Robert J. van Oostenbrugge; Julie Staals

doi:10.1161/STROKEAHA.113.003003

Incidence of Oral Anticoagulant-Associated Intracerebral Hemorrhage in the Netherlands

Angel M. R. Schols, Floris H. B. M. Schreuder^*, Elisabeth P. M. van Raak, Tobien H. C. M. L. Schreuder, Fergus A. Rooyer, Robert J. van Oostenbrugge, Julie Staals

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Web of Science)

Abstract

Background and Purpose The aim of this study was to estimate the annual adult incidence and risk of intracerebral hemorrhage (ICH) and oral anticoagulant-associated ICH (OAC-ICH) in the Netherlands. Methods We retrospectively selected all consecutive adult patients with a nontraumatic ICH seen in 1 of 3 hospitals in the region South-Limburg, the Netherlands, from 2007 to 2009. Crude incidences were age-adjusted to Dutch and European population. Results We identified 652 ICH cases, of which 168 (25.8%) were OAC associated. The adult Dutch age-adjusted annual incidence of ICH and OAC-ICH was 34.8 (95% confidence interval, 32.0-37.8) and 8.7 (95% confidence interval, 7.3-10.3) per 100 000 person-years, respectively. The absolute risk of OAC-ICH was estimated at 0.46% per patient-year of OAC treatment. Conclusions The annual incidences of ICH and OAC-ICH are relatively high in the Netherlands when compared with international literature.

Original language	English
Pages (from-to)	268-270
Journal	Stroke
Volume	45
Issue number	1
DOIs	https://doi.org/10.1161/STROKEAHA.113.003003
Publication status	Published - Jan 2014

Keywords

anticoagulants
cerebral hemorrhage
epidemiology
incidence

Access to Document

10.1161/STROKEAHA.113.003003

Cite this

@article{6838889fc5144f6c9a23f724b13c17b3,

title = "Incidence of Oral Anticoagulant-Associated Intracerebral Hemorrhage in the Netherlands",

abstract = "Background and Purpose The aim of this study was to estimate the annual adult incidence and risk of intracerebral hemorrhage (ICH) and oral anticoagulant-associated ICH (OAC-ICH) in the Netherlands. Methods We retrospectively selected all consecutive adult patients with a nontraumatic ICH seen in 1 of 3 hospitals in the region South-Limburg, the Netherlands, from 2007 to 2009. Crude incidences were age-adjusted to Dutch and European population. Results We identified 652 ICH cases, of which 168 (25.8%) were OAC associated. The adult Dutch age-adjusted annual incidence of ICH and OAC-ICH was 34.8 (95% confidence interval, 32.0-37.8) and 8.7 (95% confidence interval, 7.3-10.3) per 100 000 person-years, respectively. The absolute risk of OAC-ICH was estimated at 0.46% per patient-year of OAC treatment. Conclusions The annual incidences of ICH and OAC-ICH are relatively high in the Netherlands when compared with international literature.",

keywords = "anticoagulants, cerebral hemorrhage, epidemiology, incidence",

author = "Schols, {Angel M. R.} and Schreuder, {Floris H. B. M.} and {van Raak}, {Elisabeth P. M.} and Schreuder, {Tobien H. C. M. L.} and Rooyer, {Fergus A.} and {van Oostenbrugge}, {Robert J.} and Julie Staals",

year = "2014",

month = jan,

doi = "10.1161/STROKEAHA.113.003003",

language = "English",

volume = "45",

pages = "268--270",

journal = "Stroke",

issn = "0039-2499",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "1",

}

TY - JOUR

T1 - Incidence of Oral Anticoagulant-Associated Intracerebral Hemorrhage in the Netherlands

AU - Schols, Angel M. R.

AU - Schreuder, Floris H. B. M.

AU - van Raak, Elisabeth P. M.

AU - Schreuder, Tobien H. C. M. L.

AU - Rooyer, Fergus A.

AU - van Oostenbrugge, Robert J.

AU - Staals, Julie

PY - 2014/1

Y1 - 2014/1

N2 - Background and Purpose The aim of this study was to estimate the annual adult incidence and risk of intracerebral hemorrhage (ICH) and oral anticoagulant-associated ICH (OAC-ICH) in the Netherlands. Methods We retrospectively selected all consecutive adult patients with a nontraumatic ICH seen in 1 of 3 hospitals in the region South-Limburg, the Netherlands, from 2007 to 2009. Crude incidences were age-adjusted to Dutch and European population. Results We identified 652 ICH cases, of which 168 (25.8%) were OAC associated. The adult Dutch age-adjusted annual incidence of ICH and OAC-ICH was 34.8 (95% confidence interval, 32.0-37.8) and 8.7 (95% confidence interval, 7.3-10.3) per 100 000 person-years, respectively. The absolute risk of OAC-ICH was estimated at 0.46% per patient-year of OAC treatment. Conclusions The annual incidences of ICH and OAC-ICH are relatively high in the Netherlands when compared with international literature.

AB - Background and Purpose The aim of this study was to estimate the annual adult incidence and risk of intracerebral hemorrhage (ICH) and oral anticoagulant-associated ICH (OAC-ICH) in the Netherlands. Methods We retrospectively selected all consecutive adult patients with a nontraumatic ICH seen in 1 of 3 hospitals in the region South-Limburg, the Netherlands, from 2007 to 2009. Crude incidences were age-adjusted to Dutch and European population. Results We identified 652 ICH cases, of which 168 (25.8%) were OAC associated. The adult Dutch age-adjusted annual incidence of ICH and OAC-ICH was 34.8 (95% confidence interval, 32.0-37.8) and 8.7 (95% confidence interval, 7.3-10.3) per 100 000 person-years, respectively. The absolute risk of OAC-ICH was estimated at 0.46% per patient-year of OAC treatment. Conclusions The annual incidences of ICH and OAC-ICH are relatively high in the Netherlands when compared with international literature.

KW - anticoagulants

KW - cerebral hemorrhage

KW - epidemiology

KW - incidence

U2 - 10.1161/STROKEAHA.113.003003

DO - 10.1161/STROKEAHA.113.003003

M3 - Article

C2 - 24203841

VL - 45

SP - 268

EP - 270

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 1

ER -