Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers

Marloes T Bazelier; Frank de Vries; Joan Bentzen; Peter Vestergaard; Hubert G M Leufkens; Tjeerd-Pieter van Staa; Nils Koch-Henriksen

doi:10.1177/1352458511426739

Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers

Marloes T Bazelier, Frank de Vries^*, Joan Bentzen, Peter Vestergaard, Hubert G M Leufkens, Tjeerd-Pieter van Staa, Nils Koch-Henriksen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis.

OBJECTIVE: To estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls.

METHODS: The case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949-2007). Data were linked to the National Hospital Discharge Register (1977-2007). Patients with MS (n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls.

RESULTS: Among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33-1.46). In particular, IRRs of tibia fracture (3.36 [2.75-4.11]), femur fracture (6.66 [5.06-8.76]) and hip fracture (3.20 [2.83-3.62]) were elevated in MS patients versus controls.

CONCLUSION: Fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur.

Original language	English
Pages (from-to)	622-7
Number of pages	6
Journal	Multiple Sclerosis Journal
Volume	18
Issue number	5
DOIs	https://doi.org/10.1177/1352458511426739
Publication status	Published - May 2012
Externally published	Yes

Keywords

Adolescent
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Case-Control Studies
Denmark/epidemiology
Female
Femoral Fractures/epidemiology
Fractures, Bone/epidemiology
Hip Fractures/epidemiology
Humans
Incidence
Male
Middle Aged
Multiple Sclerosis/epidemiology
Odds Ratio
Osteoporosis/epidemiology
Registries
Risk Assessment
Risk Factors
Sex Distribution
Sex Factors
Tibial Fractures/epidemiology
Time Factors
Young Adult

Access to Document

10.1177/1352458511426739

Cite this

@article{ac45a88c512d4934a4573f6837db6061,

title = "Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers",

abstract = "BACKGROUND: Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis.OBJECTIVE: To estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls.METHODS: The case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949-2007). Data were linked to the National Hospital Discharge Register (1977-2007). Patients with MS (n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls.RESULTS: Among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33-1.46). In particular, IRRs of tibia fracture (3.36 [2.75-4.11]), femur fracture (6.66 [5.06-8.76]) and hip fracture (3.20 [2.83-3.62]) were elevated in MS patients versus controls.CONCLUSION: Fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur.",

keywords = "Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Case-Control Studies, Denmark/epidemiology, Female, Femoral Fractures/epidemiology, Fractures, Bone/epidemiology, Hip Fractures/epidemiology, Humans, Incidence, Male, Middle Aged, Multiple Sclerosis/epidemiology, Odds Ratio, Osteoporosis/epidemiology, Registries, Risk Assessment, Risk Factors, Sex Distribution, Sex Factors, Tibial Fractures/epidemiology, Time Factors, Young Adult",

author = "Bazelier, {Marloes T} and {de Vries}, Frank and Joan Bentzen and Peter Vestergaard and Leufkens, {Hubert G M} and {van Staa}, Tjeerd-Pieter and Nils Koch-Henriksen",

year = "2012",

month = may,

doi = "10.1177/1352458511426739",

language = "English",

volume = "18",

pages = "622--7",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

number = "5",

}

TY - JOUR

T1 - Incidence of fractures in patients with multiple sclerosis

T2 - the Danish National Health Registers

AU - Bazelier, Marloes T

AU - de Vries, Frank

AU - Bentzen, Joan

AU - Vestergaard, Peter

AU - Leufkens, Hubert G M

AU - van Staa, Tjeerd-Pieter

AU - Koch-Henriksen, Nils

PY - 2012/5

Y1 - 2012/5

N2 - BACKGROUND: Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis.OBJECTIVE: To estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls.METHODS: The case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949-2007). Data were linked to the National Hospital Discharge Register (1977-2007). Patients with MS (n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls.RESULTS: Among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33-1.46). In particular, IRRs of tibia fracture (3.36 [2.75-4.11]), femur fracture (6.66 [5.06-8.76]) and hip fracture (3.20 [2.83-3.62]) were elevated in MS patients versus controls.CONCLUSION: Fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur.

AB - BACKGROUND: Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis.OBJECTIVE: To estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls.METHODS: The case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949-2007). Data were linked to the National Hospital Discharge Register (1977-2007). Patients with MS (n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls.RESULTS: Among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33-1.46). In particular, IRRs of tibia fracture (3.36 [2.75-4.11]), femur fracture (6.66 [5.06-8.76]) and hip fracture (3.20 [2.83-3.62]) were elevated in MS patients versus controls.CONCLUSION: Fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Denmark/epidemiology

KW - Female

KW - Femoral Fractures/epidemiology

KW - Fractures, Bone/epidemiology

KW - Hip Fractures/epidemiology

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/epidemiology

KW - Odds Ratio

KW - Osteoporosis/epidemiology

KW - Registries

KW - Risk Assessment

KW - Risk Factors

KW - Sex Distribution

KW - Sex Factors

KW - Tibial Fractures/epidemiology

KW - Time Factors

KW - Young Adult

U2 - 10.1177/1352458511426739

DO - 10.1177/1352458511426739

M3 - Article

C2 - 22020418

SN - 1352-4585

VL - 18

SP - 622

EP - 627

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 5

ER -