Incidence and Risk Factors of the Post-thrombotic Syndrome

M. A. F. de Wolf*, C. H. A. Wittens, Rene S. Kahn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Web of Science)


Annually 1-2 in every 1000 adults will develop a deep venous thrombosis of the lower extremity. A third to half of these patients will develop the post-thrombotic syndrome (PTS). However, predicting which patients will develop the PTS remains elusive. Ipsilateral thrombosis recurrence seems to be the most important risk factor. Moreover, residual venous occlusion and valvular reflux seem to predict PTS incidence to some degree. Laboratory parameters, including D-dimers and inflammatory markers, have shown promise in predicting development of the PTS in patients and are currently under investigation. Creating a model based on all combined risk factors and patient characteristics might aid in risk stratification in individual patients.
Original languageEnglish
Pages (from-to)85-94
JournalPhlebology: The Journal of Venous Disease
Issue number1
Publication statusPublished - Mar 2012


  • post-thrombotic syndrome
  • deep venous thrombosis
  • risk factors
  • incidence

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