Incidence and management of toxicity associated with ibrutinib and idelalisib: a practical approach

Iris de Weerdt, Suzanne M. Koopmans, Arnon P. Kater*, Michel van Gelder

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

91 Citations (Web of Science)

Abstract

The use of novel B-cell receptor signaling inhibitors results in high response rates and long progression-free survival in patients with indolent B-cell malignancies, such as chronic lymphocytic leukemia, follicular lymphoma, mantle cell lymphoma and Waldenstrom macroglobulinemia. Ibrutinib, the first-in-class inhibitor of Bruton tyrosine kinase, and idelalisib, the first-in-class inhibitor of phosphatidylinositol 3-kinase delta, have recently been approved for the treatment of several indolent B-cell malignancies. These drugs are especially being used for previously unmet needs, i.e., for patients with relapsed or refractory disease, high-risk cytogenetic or molecular abnormalities, or with comor-bidities. Treatment with ibrutinib and idelalisib is generally well tolerated, even by elderly patients. However, the use of these drugs may come with toxicities that are distinct from the side effects of immunochemotherapy. In this review we discuss the most commonly reported and/or most clinically relevant adverse events associated with these B-cell receptor inhibitors, with special emphasis on recommendations for their management.

Original languageEnglish
Pages (from-to)1629-1639
Number of pages11
JournalHaematologica-the Hematology Journal
Volume102
Issue number10
DOIs
Publication statusPublished - Oct 2017

Keywords

  • CHRONIC LYMPHOCYTIC-LEUKEMIA
  • B-CELL-RECEPTOR
  • SINGLE-AGENT IBRUTINIB
  • RANDOMIZED CONTROLLED-TRIALS
  • NON-HODGKIN-LYMPHOMA
  • ATRIAL-FIBRILLATION
  • OPEN-LABEL
  • AUTOIMMUNE CYTOPENIAS
  • INHIBITOR IBRUTINIB
  • 3-KINASE P110-DELTA

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