Incidence and Classification of Postcolonoscopy Colorectal Cancers in Inflammatory Bowel Disease: A Dutch Population-Based Cohort Study

Dion S. J. Wintjens*, Roel M. M. Bogie, Tim R. A. van den Heuvel, Chantal M. C. le Clercq, Liekele E. Oostenbrug, Marielle J. L. Romberg-Camps, Jan-Willem Straathof, Laurents P. S. Stassen, Ad A. M. Masclee, Daisy M. A. E. Jonkers, Silvia Sanduleanu, Marie J. Pierik

*Corresponding author for this work

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Abstract

Background and Aims: Patients with inflammatory bowel disease [IBD] colitis are at increased risk for colorectal cancer [CRC]. We examined the proportion and most likely aetiology of potentially preventable postcolonoscopy CRCs [PCCRCs] in a population-based cohort. Furthermore, adherence to IBD surveillance guidelines was evaluated in both PCCRCs and the remainder of prevalent CRCs.

Methods: All IBD patients diagnosed from 1991 to 2011 in the South Limburg region of The Netherlands [i.e. IBDSL cohort] were included. CRC cases were cross-checked with the Dutch pathology database and cancer registry. PCCRCs were defined as cancers diagnosed within 6-60 months after a colonoscopy and were classified as attributable to 'inappropriate surveillance interval', 'inadequate bowel examination', 'incomplete resection', 'missed lesion' or 'newly developed cancer'.

Results: Twenty CRC cases were identified during 25,931 patient years of follow-up in 2,801 patients. The proportion of PCCRCs was 45.0%. Of these, 55.6% could be considered a 'missed lesion', while other possible aetiologies occurred only once. Considering both PCCRCs [n=9] and prevalent CRCs [n=11], ten were detected after publication of the surveillance guideline, but only three patients were enrolled. Moreover, 6 CRCs [30.0%] were detected before the recommended start of surveillance.

Conclusions: In the IBDSL cohort, 45.0% of all CRCs were considered to be PCCRCs, mainly classified as missed lesions. Additionally, a large proportion of CRCs in our cohort were observed before a surveillance endoscopy was performed. Therefore, stringent adherence to IBD surveillance guidelines, improving endoscopy techniques and adjusting the surveillance program may lead to a decrease in CRC incidence.

Original languageEnglish
Pages (from-to)777-783
Number of pages7
JournalJournal of Crohn's & Colitis
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2018

Keywords

  • Epidemiology
  • endoscopy
  • ULCERATIVE-COLITIS
  • COLONOSCOPIC SURVEILLANCE
  • SCREENING COLONOSCOPY
  • DECLINING RISK
  • METAANALYSIS
  • CROHNS
  • CARCINOMA
  • CONSENSUS
  • NEOPLASIA

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