@article{7323741ccb2346499a662e271ea2aa37,
title = "In vitro human cell-based models: What can they do and what are their limitations?",
abstract = "It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations?",
author = "Lutolf, \{Matthias P.\} and Milica Radisic and Jeffrey Beekman and Huh, \{Dan Dongeun\} and Meritxell Huch and Turco, \{Margherita Yayoi\} and Birgani, \{Zeinab Niloofar Tahmasebi\} and Dong Gao and Rui Yao and Hang Lin and Takanori Takebe",
note = "Funding Information: M.R. is an inventor in multiple patents covering Biowire heart-on-a-chip technology that are licensed to Valo Health. She receives royalty from these inventions. M.R. holds equity in and receives consulting fees from Quthero, Inc. She is an inventor on patents and patent applications describing regenerative peptides and biomaterials that have been licensed to Quthero, Inc. D.D.H. is a founder of Vivodyne, Inc. and holds equity in Vivodyne, Inc. and Emulate Bio, Inc. D.D.H. has a number of patent applications and issued patents related to in vitro models of human tissue. M.H. is an inventor on several patents related to organoid work. J.B. is an inventor on a patent related to organoid technology, has received consultation fees, and is principal investigator on an industry-sponsored project related to the work (Proteostasis, Eloxx Pharmaceuticals). He cofounded and has shares <5\% in FAIR Therapeutics. Full disclosures can be found at https://www.umcutrecht.nl/en/research/researchers/beekman-jeffrey-jm.",
year = "2024",
month = dec,
doi = "10.1016/j.tibtech.2024.08.015",
language = "English",
volume = "42",
pages = "1577--1582",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Ltd",
number = "12",
}