In Vitro and In Vivo Neuronal Electrotaxis: A Potential Mechanism for Restoration?

Ali Jahanshahi*, Lisa-Maria Schonfeld, Evi Lemmens, Sven Hendrix, Yasin Temel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

Electrical brain stimulation used to treat a variety of neurological and psychiatric diseases is entering a new period. The technique is well established and the potential complications are well known and generally manageable. Recent studies demonstrated that electrical fields (EFs) can enhance neuroplasticity-related processes. EFs applied in the physiological range induce migration of different neural cell types from different species in vitro. There are some evidences that also the speed and directedness of cell migration are enhanced by EFs. However, it is still unclear how electrical signals from the extracellular space are translated into intracellular actions resulting in the so-called electrotaxis phenomenon. Here, we aim to provide a comprehensive review of the data on responses of cells to electrical stimulation and the relation to functional recovery.
Original languageEnglish
Pages (from-to)1005-1016
JournalMolecular Neurobiology
Volume49
Issue number2
DOIs
Publication statusPublished - Apr 2014

Keywords

  • Brain repair
  • Brain stimulation
  • Electrical fields
  • Electrotaxis
  • Regeneration

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