In Utero Exposure to Compounds with Dioxin-like Activity and Birth Outcomes

Marina Vafeiadi, Silvia Agramunt, Marie Pedersen, Harrie Besselink, Leda Chatzi, Eleni Fthenou, Sarah Fleming, Laura J. Hardie, John Wright, Lisbeth E. Knudsen, Jeanette K. S. Nielsen, Jordi Sunyer, Ramon Carreras, Gunnar Brunborg, Kristine B. Gutzkow, Unni C. Nygaard, Martinus Lovik, Soterios A. Kyrtopoulos, Dan Segerback, Domenico F. MerloJos C. Kleinjans, Martine Vrijheid, Manolis Kogevinas*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)


Background: Maternal exposure to dioxins and dioxin-like compounds may affect fetal growth and development. We evaluated the association between in utero dioxin-like activity and birth outcomes in a prospective European mother-child study. Methods: We measured dioxin-like activity in maternal and cord blood plasma samples collected at delivery using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX) bioassay in 967 mother-child pairs, in Denmark, Greece, Norway, Spain, and England. Multiple linear regression models were used to investigate the associations with birth weight, gestational age, and head circumference. Results: Plasma dioxin-like activity was higher in maternal sample than in cord samples. Birth weight was lower with medium (-58 g [95% confidence interval (CI) = -176 to 62]) and high (-82 g [-216 to 53]) tertiles of exposure (cord blood) compared with the lowest tertile. Gestational age was shorter by approximately half a week in the highest compared with the lowest (-0.4 weeks [95% CI = -0.8 to -0.1]). This association was stronger in boys than in girls, although the statistical evidence for interaction was weak (P = 0.22). Analysis based on CALUX-toxic equivalents expressed per milliliter of plasma showed similar trends. We found no association between dioxin-like activity in maternal plasma and birth outcomes. Conclusions: Results from this international general population study suggest an association between low-level prenatal dioxin-like activity and shorter gestational age, particularly in boys, with weaker associations for birth weight.
Original languageEnglish
Pages (from-to)215-224
Issue number2
Publication statusPublished - Mar 2014

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