Improving a probabilistic cytoarchitectonic atlas of auditory cortex using a novel method for inter-individual alignment

Omer Faruk Gulban*, Rainer Goebel, Michelle Moerel, Daniel Zachlod, Hartmut Mohlberg, Katrin Amunts, Federico de Martino

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)

Abstract

The human superior temporal plane, the site of the auditory cortex, displays high inter-individual macro-anatomical variation. This questions the validity of curvature-based alignment (CBA) methods for in vivo imaging data. Here, we have addressed this issue by developing CBA+, which is a cortical surface registration method that uses prior macro-anatomical knowledge. We validate this method by using cytoarchitectonic areas on 10 individual brains (which we make publicly available). Compared to volumetric and standard surface registration, CBA+ results in a more accurate cytoarchitectonic auditory atlas. The improved correspondence of micro-anatomy following the improved alignment of macro-anatomy validates the superiority of CBA+ compared to CBA. In addition, we use CBA+ to align in vivo and postmortem data. This allows projection of functional and anatomical information collected in vivo onto the cytoarchitectonic areas, which has the potential to contribute to the ongoing debate on the parcellation of the human auditory cortex.

Original languageEnglish
Article numbere56963
Number of pages29
JournalElife
Volume9
DOIs
Publication statusPublished - 5 Aug 2020

Keywords

  • CEREBRAL-CORTEX
  • NATURAL SOUNDS
  • CORTICAL AREAS
  • IMAGE-ANALYSIS
  • HUMAN BRAIN
  • PARCELLATION
  • IDENTIFICATION
  • SEGMENTATION
  • LOCALIZATION
  • BRAINVOYAGER

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