Improvement of small fiber neuropathy in a sarcoidosis patient after treatment with infliximab

E. Hoitsma, C.G. Faber, H.M. van Santen-Hoeufft, J. de Vries, J.P. Reulen, M. Drent*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Web of Science)


We describe a patient with severe small fiber neuropathy (SFN) accompanied by autonomic involvement, who was experimentally treated with infliximab, an anti-tumour necrosis factor-alpha (TNF-alpha) therapy. Six months after this treatment was started his symptoms completely resolved. Until now they did not return. Repeated temperature threshold testing (TTT) as well as cardiovascular autonomic function test clearly improved after one year therapy. This case reveals two important issues. First, it shows that SFN seems not an irreversible disorder, even in severe cases. Second, TNF-alpha may be a crucial cytokine in the pathogenesis of SFN in sarcoidosis and eventually also in other immune mediated inflammatory diseases.
Original languageEnglish
Pages (from-to)73-77
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Issue number1
Publication statusPublished - 1 Jan 2006

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