Improved outcomes due to changes in organization of care for patients with ovarian cancer in the Netherlands

F. A. Eggink; C. H. Mom; R. F. Kruitwagen; A. K. Reyners; W. J. Van Driel; L. F. Massuger; G. C. Niemeijer; A. G. Van der Zee; M. A. Van der Aa; H. W. Nijman

doi:10.1016/j.ygyno.2016.04.012

Improved outcomes due to changes in organization of care for patients with ovarian cancer in the Netherlands

F. A. Eggink, C. H. Mom, R. F. Kruitwagen, A. K. Reyners, W. J. Van Driel, L. F. Massuger, G. C. Niemeijer, A. G. Van der Zee, M. A. Van der Aa, H. W. Nijman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives. Objectives of this study were to evaluate the effect of changes in patterns of care, for example centralization and treatment sequence, on surgical outcome and survival in patients with epithelial ovarian cancer (EOC). Methods. Patients diagnosed with FIGO stage IIB-IV EOC (2004-2013) were selected from the Netherlands Cancer Registry. Primary outcomes were surgical outcome (extent of macroscopic residual tumor after surgery) and overall survival. Changes in treatment sequence (primary debulking surgery and adjuvant chemotherapy (PDS + ACT) or neo-adjuvant chemotherapy and interval debulking surgery (NACT + IDS)), hospital type and annual hospital volume were also evaluated. Results. Patient and tumor characteristics of 7987 patients were retrieved. Most patients were diagnosed with stage HI-IV EOC. The average annual case-load per hospital increased from 8 to 28. More patients received an optimal cytoreduction (tumor residue = 20 cytoreductive surgeries annually), 80% in medium (10-19 surgeries) and 71% in small hospitals (

Original language	English
Pages (from-to)	524-530
Journal	Gynecologic Oncology
Volume	141
Issue number	3
DOIs	https://doi.org/10.1016/j.ygyno.2016.04.012
Publication status	Published - Jun 2016

Keywords

Ovarian cancer
Pattern of care
Survival
Surgical outcome
Neo-adjuvant chemotherapy

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10.1016/j.ygyno.2016.04.012

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Eggink, F. A., Mom, C. H., Kruitwagen, R. F., Reyners, A. K., Van Driel, W. J., Massuger, L. F., Niemeijer, G. C., Van der Zee, A. G., Van der Aa, M. A., & Nijman, H. W. (2016). Improved outcomes due to changes in organization of care for patients with ovarian cancer in the Netherlands. Gynecologic Oncology, 141(3), 524-530. https://doi.org/10.1016/j.ygyno.2016.04.012

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title = "Improved outcomes due to changes in organization of care for patients with ovarian cancer in the Netherlands",

abstract = "Objectives. Objectives of this study were to evaluate the effect of changes in patterns of care, for example centralization and treatment sequence, on surgical outcome and survival in patients with epithelial ovarian cancer (EOC). Methods. Patients diagnosed with FIGO stage IIB-IV EOC (2004-2013) were selected from the Netherlands Cancer Registry. Primary outcomes were surgical outcome (extent of macroscopic residual tumor after surgery) and overall survival. Changes in treatment sequence (primary debulking surgery and adjuvant chemotherapy (PDS + ACT) or neo-adjuvant chemotherapy and interval debulking surgery (NACT + IDS)), hospital type and annual hospital volume were also evaluated. Results. Patient and tumor characteristics of 7987 patients were retrieved. Most patients were diagnosed with stage HI-IV EOC. The average annual case-load per hospital increased from 8 to 28. More patients received an optimal cytoreduction (tumor residue = 20 cytoreductive surgeries annually), 80% in medium (10-19 surgeries) and 71% in small hospitals (",

keywords = "Ovarian cancer, Pattern of care, Survival, Surgical outcome, Neo-adjuvant chemotherapy",

author = "Eggink, {F. A.} and Mom, {C. H.} and Kruitwagen, {R. F.} and Reyners, {A. K.} and {Van Driel}, {W. J.} and Massuger, {L. F.} and Niemeijer, {G. C.} and {Van der Zee}, {A. G.} and {Van der Aa}, {M. A.} and Nijman, {H. W.}",

year = "2016",

month = jun,

doi = "10.1016/j.ygyno.2016.04.012",

language = "English",

volume = "141",

pages = "524--530",

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T1 - Improved outcomes due to changes in organization of care for patients with ovarian cancer in the Netherlands

AU - Eggink, F. A.

AU - Mom, C. H.

AU - Kruitwagen, R. F.

AU - Reyners, A. K.

AU - Van Driel, W. J.

AU - Massuger, L. F.

AU - Niemeijer, G. C.

AU - Van der Zee, A. G.

AU - Van der Aa, M. A.

AU - Nijman, H. W.

PY - 2016/6

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N2 - Objectives. Objectives of this study were to evaluate the effect of changes in patterns of care, for example centralization and treatment sequence, on surgical outcome and survival in patients with epithelial ovarian cancer (EOC). Methods. Patients diagnosed with FIGO stage IIB-IV EOC (2004-2013) were selected from the Netherlands Cancer Registry. Primary outcomes were surgical outcome (extent of macroscopic residual tumor after surgery) and overall survival. Changes in treatment sequence (primary debulking surgery and adjuvant chemotherapy (PDS + ACT) or neo-adjuvant chemotherapy and interval debulking surgery (NACT + IDS)), hospital type and annual hospital volume were also evaluated. Results. Patient and tumor characteristics of 7987 patients were retrieved. Most patients were diagnosed with stage HI-IV EOC. The average annual case-load per hospital increased from 8 to 28. More patients received an optimal cytoreduction (tumor residue = 20 cytoreductive surgeries annually), 80% in medium (10-19 surgeries) and 71% in small hospitals (

AB - Objectives. Objectives of this study were to evaluate the effect of changes in patterns of care, for example centralization and treatment sequence, on surgical outcome and survival in patients with epithelial ovarian cancer (EOC). Methods. Patients diagnosed with FIGO stage IIB-IV EOC (2004-2013) were selected from the Netherlands Cancer Registry. Primary outcomes were surgical outcome (extent of macroscopic residual tumor after surgery) and overall survival. Changes in treatment sequence (primary debulking surgery and adjuvant chemotherapy (PDS + ACT) or neo-adjuvant chemotherapy and interval debulking surgery (NACT + IDS)), hospital type and annual hospital volume were also evaluated. Results. Patient and tumor characteristics of 7987 patients were retrieved. Most patients were diagnosed with stage HI-IV EOC. The average annual case-load per hospital increased from 8 to 28. More patients received an optimal cytoreduction (tumor residue = 20 cytoreductive surgeries annually), 80% in medium (10-19 surgeries) and 71% in small hospitals (

KW - Ovarian cancer

KW - Pattern of care

KW - Survival

KW - Surgical outcome

KW - Neo-adjuvant chemotherapy

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DO - 10.1016/j.ygyno.2016.04.012

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SN - 0090-8258

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JO - Gynecologic Oncology

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