Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Alice C. O'Farrell, Monika A. Jarzabek, Andreas U. Lindner, Steven Carberry, Emer Conroy, Ian S. Miller, Kate Connor, Liam Shiels, Eugenia R. Zanella, Federico Lucantoni, Adam Lafferty, Kieron White, Mariangela Meyer Villamandos, Patrick Dicker, William M. Gallagher, Simon A. Keek, Sebastian Sanduleanu, Philippe Lambin, Henry C. Woodruff, Andrea BertottiLivio Trusolino, Annette T. Byrne, Jochen H. M. Prehn*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number2978
Number of pages19
JournalCancers
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 2020

Keywords

  • ABT-199
  • Venetoclax
  • colorectal cancer
  • BCL-2
  • FOLFOX
  • PDX
  • preclinical imaging
  • radiomics
  • systems biology
  • deterministic modelling
  • CELL-DEATH
  • COLON-CANCER
  • RADIOMICS
  • APOPTOSIS
  • BCL-X(L)
  • MITOCHONDRIA
  • RESISTANCE
  • RESPONSES
  • PROTEINS
  • GROWTH

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