Implementing pharmacogenetics to personalize antiplatelet therapy after myocardial infarction

Research output: ThesisDoctoral ThesisExternal prepared

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Abstract

This dissertation studied whether it is possible to let a simple genetic test determine the choice for the blood thinner that patients have to use after a heart infarct. It also investigated whether this would lead to a reduction in the number of side-effects compared to the current standard treatment with stronger blood thinners. This international study with almost 2500 patients from the Netherlands, Belgium and Italy indeed showed that it is possible to have these results available quickly (within 24 hours) and to adjust the therapy accordingly. The study showed that patients in whom the blood thinner was selected on the basis of the genetic research had fewer bleedings, without an increased risk of a new heart attack, cerebral infarction or death. It was also shown that this strategy leads to a reduction in healthcare costs and an improvement in quality of life.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • ten Berg, Jur, Supervisor
  • van 't Hof, Arnoud, Supervisor
  • Deneer, V.H.M., Co-Supervisor, External person
  • Hermanides, R.S., Co-Supervisor, External person
Award date3 Dec 2021
Place of PublicationMaastricht
Publisher
Print ISBNs9789464234374
DOIs
Publication statusPublished - 2021

Keywords

  • heart attack
  • personalized medicine
  • blood thinners

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