@article{af15200105144e5c8d78ddfee1f04919,
title = "Implementing computational modeling in tissue engineering: where disciplines meet",
abstract = "In recent years, the mathematical and computational sciences have developed novel methodologies and insights that can aid in designing advanced bioreactors, microfluidic set-ups or organ-on-chip devices, in optimizing culture conditions, or predicting long-term behavior of engineered tissues in vivo. In this review, we introduce the concept of computational models and how they can be integrated in an interdisciplinary workflow for Tissue Engineering and Regenerative Medicine (TERM). We specifically aim this review of general concepts and examples at experimental scientists with little or no computational modeling experience. We also describe the contribution of computational models in understanding TERM processes and in advancing the TERM field by providing novel insights.",
keywords = "BIOMATERIALS, CELL-MEDIATED COMPACTION, COLLAGEN, DESIGN, HEART-VALVES, HUMAN ARTICULAR CHONDROCYTES, IN-VITRO, OPTIMIZATION, OXYGEN-TENSION, SYSTEMS BIOLOGY, experimental integration, mathematical modeling, model calibration, model validation, signal transduction",
author = "Post, {Janine Nicole} and Sandra Loerakker and Roeland Merks and Aur{\'e}lie Carlier",
note = "Funding Information: J.N.P. gratefully acknowledges the Dutch Arthritis Foundation grant no. 17-2-402, and the Dutch Research Council (NWO) grant no. OCENW.GROOT.2019.079. S.L. acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Program (ERC StG MechanoSignaling [grant agreement no. 802967]). R.M.H.M. is supported by Nederlandse Organisatie voor Wetenschappelijk Onderzoek grant NWO/ENW-VICI 865.17.004. Funding Information: J.N.P. gratefully acknowledges the Dutch Arthritis Foundation grant no. 17-2-402, and the Dutch Research Council (NWO) grant no. OCENW.GROOT.2019.079. S.L. acknowledges funding from the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 Research and Innovation Program (ERC StG MechanoSignaling [grant agreement no. 802967]). R.M.H.M. is supported by Neder-landse Organisatie voor Wetenschappelijk Onderzoek grant NWO/ENW-VICI 865.17.004. Publisher Copyright: {\textcopyright} Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.",
year = "2022",
month = jun,
day = "1",
doi = "10.1089/ten.TEA.2021.0215",
language = "English",
volume = "28",
pages = "542--554",
journal = "Tissue Engineering. Part A ",
issn = "2152-4947",
publisher = "Mary Ann Liebert Inc.",
number = "11-12",
}