Abstract
IntroductionCervical cancer screening primarily with high risk human papillomavirus (hr-HPV) proved to be more sensitive, in detecting CIN grade 2 or worse (CIN2 +), than the traditional cervical cytology. Primary hr-HPV detection opened up the possibility for vaginal self-sampling, as hr-HPV detection is easy to perform on a vaginal self-sample and showed to be reliable. The aim of this review is to explore the role of HPV self-sampling as a strategy to increase the participation rate in cervical screening programs. MethodsPubMed search on self-sampling HPV; including articles published within last 10 years; Meta-analyse, Randomized Controlled Trial, Review or Systematic Review.ResultsThe literature shows that HPV vaginal self-sampling is feasible, highly acceptable and above all has a high diagnostic accuracy in detecting HPV and CIN2 +. Furthermore, HPV self-sampling followed by Pap smear triage in hr-HPV positive women is cost-effective. Additionally offering mailed self-sample kits, ideally in combination with education, has been proven to improve participation and subsequently CIN2+ detection. ConclusionImplementation of HPV self-sampling in cervical screening programs offers opportunities to reach under screened women, not only in high-income countries, but especially in low- and medium-income countries and among ethnic minority women.
Original language | English |
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Article number | 54 |
Number of pages | 6 |
Journal | Indian Journal of Gynecologic Oncology |
Volume | 19 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Sept 2021 |
Keywords
- HPV self-sampling
- Underscreened women
- Cervical intraepithelial neoplasia (CIN)
- Cost-effectiveness
- HUMAN-PAPILLOMAVIRUS DETECTION
- RANDOMIZED-TRIAL
- PAP-SMEAR
- CANCER
- WOMEN
- RISK
- POPULATION
- CLINICIAN
- CYTOLOGY