Impaired SMAD1/5 Mechanotransduction and Cx37 (Connexin37) Expression Enable Pathological Vessel Enlargement and Shunting

Hanna M Peacock, Ashkan Tabibian, Nathan Criem, Vincenza Caolo, Lauriane Hamard, Astrid Deryckere, Jacques-Antoine Haefliger, Brenda R Kwak, An Zwijsen, Elizabeth A V Jones

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)e87-e104
Number of pages18
JournalArteriosclerosis Thrombosis and Vascular Biology
Volume40
Issue number4
DOIs
Publication statusPublished - Apr 2020
Externally publishedYes

Keywords

  • Activin Receptors, Type II/metabolism
  • Animals
  • Arteriovenous Malformations/genetics
  • Capillaries/pathology
  • Cells, Cultured
  • Connexins/genetics
  • Down-Regulation
  • Embryo, Mammalian
  • Endoglin/metabolism
  • Endothelial Cells/metabolism
  • Female
  • Growth Differentiation Factor 2/metabolism
  • Humans
  • Male
  • Mechanotransduction, Cellular
  • Mice, Knockout
  • Smad1 Protein/genetics
  • Smad5 Protein/genetics
  • Up-Regulation
  • Vascular Remodeling
  • arteriovenous malformation
  • SIGNALING PATHWAYS
  • ENDOTHELIAL-CELL PROLIFERATION
  • vascular remodeling
  • VASCULAR GROWTH
  • MICE
  • TGF-BETA RECEPTOR
  • bone morphogenetic proteins
  • ARTERIOVENOUS-MALFORMATIONS
  • TELANGIECTASIA
  • HEMODYNAMIC-CHANGES
  • ENDOGLIN
  • hemodynamics
  • ALK1
  • Connexin37

Cite this