Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma

Okan W. Bastian*, Anne Kuijer, Leo Koenderman, Rebecca K. Stellato, Wouter W. van Solinge, Luke P. H. Leenen, Taco J. Blokhuis

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)


Animal studies have shown that the systemic inflammatory response to major injury impairs bone regeneration. It remains unclear whether the systemic immune response contributes to impairment of fracture healing in multitrauma patients. It is well known that systemic inflammatory changes after major trauma affect leukocyte kinetics. We therefore retrospectively compared the cellular composition of peripheral blood during the first 2 weeks after injury between multitrauma patients with normal (n=48) and impaired (n=32) fracture healing of the tibia. The peripheral blood-count curves of leukocytes, neutrophils, monocytes, and thrombocytes differed significantly between patients with normal and impaired fracture healing during the first 2 weeks after trauma (P-values were 0.0122, 0.0083, 0.0204, and
Original languageEnglish
JournalJournal of Inflammation Research
Publication statusPublished - 2016


  • SIRS
  • inflammation
  • neutrophils
  • myelopoiesis
  • regeneration

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