Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome

A. Papadaki, M. Linardakis, M. Plada, T.M. Larsen, C.T. Damsgaard, M.A. van Baak, S. Jebb, A.F. Pfeiffer, J.A. Martinez, T. Handjieva Darlenska, M. Kunesova, C. Holst, W.H. Saris, A. Astrup, A. Kafatos

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Abstract

OBJECTIVES: We investigated the effects of weight loss and maintenance that varied with regard to protein content and glycemic index (GI) on syndrome (MetSyn) status. METHODS: Secondary analyses were performed Diet, Obesity and Genes (DiOGenes) study (2006-2008), a randomized dietary intervention. Nine hundred and thirty-eight overweight and obese from eight European countries entered an 8-wk low-calorie-diet period. hundred and seventy-three adults who lost at least 8% of their body randomized to one of five ad libitum diets for 6 mo: 1) low-protein (LGI); 2) LP/high-GI (HGI); 3) high-protein (HP)/LGI; 4) HP/HGI; and 5) diet. MetSyn prevalence and a standardized MetSyn score were assessed at baseline, after the low-calorie diet, and after the intervention. loss among participants while on the low-calorie diet significantly MetSyn prevalence (33.9% versus 15.9%; P < 0.001) and MetSyn score (- -4.45; P < 0.001). During weight maintenance, significant changes in were observed between the groups, with the highest increase detected in LP/HGI group (P = 0.039, partial eta2 = 0.023). Protein, GI, and their interaction did not have isolated effects on study outcomes. protein nor GI affected MetSyn status in this sample of European obese adults. However, a diet with a combination of an increased protein-to-carbohydrate ratio with low-GI foods had beneficial effects factors.
Original languageEnglish
Pages (from-to)410-417
JournalNutrition
Volume30
Issue number4
DOIs
Publication statusPublished - 1 Jan 2014

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Papadaki, A., Linardakis, M., Plada, M., Larsen, T. M., Damsgaard, C. T., van Baak, M. A., Jebb, S., Pfeiffer, A. F., Martinez, J. A., Handjieva Darlenska, T., Kunesova, M., Holst, C., Saris, W. H., Astrup, A., & Kafatos, A. (2014). Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome. Nutrition, 30(4), 410-417. https://doi.org/10.1016/j.nut.2013.09.001