Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial

A.H. Tavenier; R.S. Hermanides; J.P. Ottervanger; S.V. Belitser; O.H. Klungel; Arnoud W.J. van't Hof; ON-TIME 3 Investigators

doi:10.1016/j.ahj.2021.08.011

Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial

A.H. Tavenier, R.S. Hermanides^*, J.P. Ottervanger, S.V. Belitser, O.H. Klungel, Arnoud W.J. van't Hof, ON-TIME 3 Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

Vomiting is associated with lower levels of ticagrelor concentration and higher platelet reactivity in the early hours of ST -elevation myocardial infarction. These results support reloading with a ticagrelor loading dose and/or treatment with intra-venous platelet inhibitors when patients vomit. (Am HeartJ 2022;243:39-42.)

Original language	English
Pages (from-to)	39-42
Number of pages	4
Journal	American Heart Journal
Volume	243
DOIs	https://doi.org/10.1016/j.ahj.2021.08.011
Publication status	Published - 1 Jan 2022

Keywords

SEGMENT ELEVATION
TASK-FORCE
MANAGEMENT

Access to Document

10.1016/j.ahj.2021.08.011

Cite this

Tavenier, A. H., Hermanides, R. S., Ottervanger, J. P., Belitser, S. V., Klungel, O. H., van't Hof, A. W. J., & ON-TIME 3 Investigators (2022). Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial. American Heart Journal, 243, 39-42. https://doi.org/10.1016/j.ahj.2021.08.011

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abstract = "Vomiting is associated with lower levels of ticagrelor concentration and higher platelet reactivity in the early hours of ST -elevation myocardial infarction. These results support reloading with a ticagrelor loading dose and/or treatment with intra-venous platelet inhibitors when patients vomit. (Am HeartJ 2022;243:39-42.)",

keywords = "SEGMENT ELEVATION, TASK-FORCE, MANAGEMENT",

author = "A.H. Tavenier and R.S. Hermanides and J.P. Ottervanger and S.V. Belitser and O.H. Klungel and {van't Hof}, {Arnoud W.J.} and {ON-TIME 3 Investigators}",

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year = "2022",

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doi = "10.1016/j.ahj.2021.08.011",

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Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial. / Tavenier, A.H.; Hermanides, R.S.; Ottervanger, J.P. et al.
In: American Heart Journal, Vol. 243, 01.01.2022, p. 39-42.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

TY - JOUR

T1 - Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial

AU - Tavenier, A.H.

AU - Hermanides, R.S.

AU - Ottervanger, J.P.

AU - Belitser, S.V.

AU - Klungel, O.H.

AU - van't Hof, Arnoud W.J.

AU - ON-TIME 3 Investigators

PY - 2022/1/1

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N2 - Vomiting is associated with lower levels of ticagrelor concentration and higher platelet reactivity in the early hours of ST -elevation myocardial infarction. These results support reloading with a ticagrelor loading dose and/or treatment with intra-venous platelet inhibitors when patients vomit. (Am HeartJ 2022;243:39-42.)

AB - Vomiting is associated with lower levels of ticagrelor concentration and higher platelet reactivity in the early hours of ST -elevation myocardial infarction. These results support reloading with a ticagrelor loading dose and/or treatment with intra-venous platelet inhibitors when patients vomit. (Am HeartJ 2022;243:39-42.)

KW - SEGMENT ELEVATION

KW - TASK-FORCE

KW - MANAGEMENT

U2 - 10.1016/j.ahj.2021.08.011

DO - 10.1016/j.ahj.2021.08.011

M3 - Comment/Letter to the editor

C2 - 34547260

SN - 0002-8703

VL - 243

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JO - American Heart Journal

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