Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease

C.G.N. Voorend; M. van Oevelen; M. Nieberg; Y. Meuleman; C.F.M. Franssen; H. Joosten; N.C. Berkhout-Byrne; A.C. Abrahams; S.P. Mooijaart; W.J.W. Bos; M. van Buren; POLDER Investigators

doi:10.1186/s12877-021-02593-0

Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease

C.G.N. Voorend^*, M. van Oevelen, M. Nieberg, Y. Meuleman, C.F.M. Franssen, H. Joosten, N.C. Berkhout-Byrne, A.C. Abrahams, S.P. Mooijaart, W.J.W. Bos, M. van Buren, POLDER Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Web of Science)

Abstract

Background: Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease.Methods: An ongoing Dutch multicentre prospective cohort study enrols patients of >= 70 years with an eGFR < 20 mL/min/1.73m(2) from October 2018 onward. With additional questionnaires during the pandemic (May-June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally.Results: The 82 included patients had a median age of 77.5 years (interquartile range 73.9-82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar.Conclusions: Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important.

Original language	English
Article number	650
Number of pages	10
Journal	BMC Geriatrics
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12877-021-02593-0
Publication status	Published - 19 Nov 2021

Keywords

ASSOCIATION
Aged
CKD
Chronic kidney diseases
Coronavirus disease-2019 (COVID-19) pandemic
DIALYSIS
HOSPITAL ANXIETY
Mental health
PREVALENCE
Quality of life
SCALE
SHORT-FORM 36
RISK
PEOPLE

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Cite this

Voorend, C. G. N., van Oevelen, M., Nieberg, M., Meuleman, Y., Franssen, C. F. M., Joosten, H., Berkhout-Byrne, N. C., Abrahams, A. C., Mooijaart, S. P., Bos, W. J. W., van Buren, M., & POLDER Investigators (2021). Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease. BMC Geriatrics, 21(1), [650]. https://doi.org/10.1186/s12877-021-02593-0

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title = "Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease",

abstract = "Background: Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease.Methods: An ongoing Dutch multicentre prospective cohort study enrols patients of >= 70 years with an eGFR < 20 mL/min/1.73m(2) from October 2018 onward. With additional questionnaires during the pandemic (May-June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally.Results: The 82 included patients had a median age of 77.5 years (interquartile range 73.9-82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar.Conclusions: Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important.",

keywords = "ASSOCIATION, Aged, CKD, Chronic kidney diseases, Coronavirus disease-2019 (COVID-19) pandemic, DIALYSIS, HOSPITAL ANXIETY, Mental health, PREVALENCE, Quality of life, SCALE, SHORT-FORM 36, RISK, PEOPLE",

author = "C.G.N. Voorend and {van Oevelen}, M. and M. Nieberg and Y. Meuleman and C.F.M. Franssen and H. Joosten and N.C. Berkhout-Byrne and A.C. Abrahams and S.P. Mooijaart and W.J.W. Bos and {van Buren}, M. and {POLDER Investigators}",

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month = nov,

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doi = "10.1186/s12877-021-02593-0",

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volume = "21",

journal = "BMC Geriatrics",

issn = "1471-2318",

publisher = "BioMed Central Ltd",

number = "1",

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Voorend, CGN, van Oevelen, M, Nieberg, M, Meuleman, Y, Franssen, CFM, Joosten, H, Berkhout-Byrne, NC, Abrahams, AC, Mooijaart, SP, Bos, WJW, van Buren, M & POLDER Investigators 2021, 'Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease', BMC Geriatrics, vol. 21, no. 1, 650. https://doi.org/10.1186/s12877-021-02593-0

TY - JOUR

T1 - Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease

AU - Voorend, C.G.N.

AU - van Oevelen, M.

AU - Nieberg, M.

AU - Meuleman, Y.

AU - Franssen, C.F.M.

AU - Joosten, H.

AU - Berkhout-Byrne, N.C.

AU - Abrahams, A.C.

AU - Mooijaart, S.P.

AU - Bos, W.J.W.

AU - van Buren, M.

AU - POLDER Investigators

PY - 2021/11/19

Y1 - 2021/11/19

N2 - Background: Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease.Methods: An ongoing Dutch multicentre prospective cohort study enrols patients of >= 70 years with an eGFR < 20 mL/min/1.73m(2) from October 2018 onward. With additional questionnaires during the pandemic (May-June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally.Results: The 82 included patients had a median age of 77.5 years (interquartile range 73.9-82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar.Conclusions: Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important.

AB - Background: Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease.Methods: An ongoing Dutch multicentre prospective cohort study enrols patients of >= 70 years with an eGFR < 20 mL/min/1.73m(2) from October 2018 onward. With additional questionnaires during the pandemic (May-June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally.Results: The 82 included patients had a median age of 77.5 years (interquartile range 73.9-82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar.Conclusions: Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important.

KW - ASSOCIATION

KW - Aged

KW - CKD

KW - Chronic kidney diseases

KW - Coronavirus disease-2019 (COVID-19) pandemic

KW - DIALYSIS

KW - HOSPITAL ANXIETY

KW - Mental health

KW - PREVALENCE

KW - Quality of life

KW - SCALE

KW - SHORT-FORM 36

KW - RISK

KW - PEOPLE

U2 - 10.1186/s12877-021-02593-0

DO - 10.1186/s12877-021-02593-0

M3 - Article

C2 - 34798817

VL - 21

JO - BMC Geriatrics

JF - BMC Geriatrics

SN - 1471-2318

IS - 1

M1 - 650

ER -