Abstract
It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.
Original language | English |
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Pages (from-to) | 403-409 |
Journal | Current Hypertension Reports |
Volume | 14 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 2012 |
Keywords
- Hypertension
- Blood pressure
- Angiotensin
- AT(2)R
- Renin-angiotensin system
- RAS
- Compound 21
- C21
- Inflammation
- Antihypertensive drug therapy