Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond

Sebastien Foulquier; U. Muscha Steckelings; Thomas Unger

doi:10.1007/s11906-012-0291-6

Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond

Sebastien Foulquier, U. Muscha Steckelings, Thomas Unger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Web of Science)

28 Downloads (Pure)

Abstract

It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.

Original language	English
Pages (from-to)	403-409
Journal	Current Hypertension Reports
Volume	14
Issue number	5
DOIs	https://doi.org/10.1007/s11906-012-0291-6
Publication status	Published - Oct 2012

Keywords

Hypertension
Blood pressure
Angiotensin
AT(2)R
Renin-angiotensin system
RAS
Compound 21
C21
Inflammation
Antihypertensive drug therapy

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10.1007/s11906-012-0291-6

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Cite this

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title = "Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond",

abstract = "It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.",

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author = "Sebastien Foulquier and Steckelings, {U. Muscha} and Thomas Unger",

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AU - Foulquier, Sebastien

AU - Steckelings, U. Muscha

AU - Unger, Thomas

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N2 - It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.

AB - It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.

KW - Hypertension

KW - Blood pressure

KW - Angiotensin

KW - AT(2)R

KW - Renin-angiotensin system

KW - RAS

KW - Compound 21

KW - C21

KW - Inflammation

KW - Antihypertensive drug therapy

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