Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond

Sebastien Foulquier; U. Muscha Steckelings; Thomas Unger

doi:10.1007/s11906-012-0291-6

Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond

Sebastien Foulquier, U. Muscha Steckelings, Thomas Unger^*

^*Corresponding author for this work

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Abstract

It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.

Original language	English
Pages (from-to)	403-409
Journal	Current Hypertension Reports
Volume	14
Issue number	5
DOIs	https://doi.org/10.1007/s11906-012-0291-6
Publication status	Published - Oct 2012

Keywords

Hypertension
Blood pressure
Angiotensin
AT(2)R
Renin-angiotensin system
RAS
Compound 21
C21
Inflammation
Antihypertensive drug therapy

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10.1007/s11906-012-0291-6

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title = "Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond",

abstract = "It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.",

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author = "Sebastien Foulquier and Steckelings, {U. Muscha} and Thomas Unger",

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T1 - Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond

AU - Foulquier, Sebastien

AU - Steckelings, U. Muscha

AU - Unger, Thomas

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N2 - It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.

AB - It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.

KW - Hypertension

KW - Blood pressure

KW - Angiotensin

KW - AT(2)R

KW - Renin-angiotensin system

KW - RAS

KW - Compound 21

KW - C21

KW - Inflammation

KW - Antihypertensive drug therapy

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DO - 10.1007/s11906-012-0291-6

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EP - 409

JO - Current Hypertension Reports

JF - Current Hypertension Reports

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ER -

Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond

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Keywords

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