@inbook{efba87db175f4a9eae93e0397f03ed9c,
title = "Impact of Nanoparticles on Dendritic Cells",
abstract = "Dendritic cells (DCs) are pivotal in the initiation of the adaptive immune response. DCs undergo maturation, a process central to their functioning, where immature DCs ingest protein antigens and mature DCs present peptides to naive T cells. Various types of nanoparticles (NPs) can influence the process of DC maturation and by that the immune response. Chemical composition, size, and surface modification have been shown to affect DC maturation; chemical composition and size effects on the direction (Th1/Th2/Th17) of the immune response have been observed. Further studies studying series of NP are required to further delineate the particle characteristics that determine these effects.",
keywords = "Cell surface marker, Cytokine, DC-SIGN, Dendritic cell, Maturation",
author = "Vandebriel, {Rob J.} and {van Loveren}, Henk",
note = "Publisher Copyright: {\textcopyright} 2020, Springer Nature Switzerland AG.",
year = "2020",
month = jan,
day = "1",
doi = "10.1007/978-3-030-33962-3_5",
language = "English",
isbn = "978-3-030-33961-6",
series = "Molecular and Integrative Toxicology",
publisher = "Springer, Cham",
pages = "73--82",
editor = "Bonner, {James C. } and Brown, {Jared M.}",
booktitle = "Interaction of Nanomaterials with the Immune System",
address = "Switzerland",
edition = "1",
}