Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients

Andreas Kroh*, Diane Uschner, Toine Lodewick, Roman M. Eickhoff, Wenzel Schoning, Florian T. Ulmer, Ulf P. Neumann, Marcel Binneboesel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Web of Science)

Abstract

Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma.

Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level (L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated.

Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic (P=0.035) and sarcopenic obese (P=0.048) patients as well as a trend favoring obese (P=0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival.

Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. (C) 2018 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)28-37
Number of pages10
JournalHepatobiliary & Pancreatic Diseases International
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2019

Keywords

  • Hepatocellular carcinoma
  • Sarcopenia
  • Obesity
  • Sarcopenic obesity
  • Liver resection
  • SKELETAL-MUSCLE DEPLETION
  • SARCOPENIC OBESITY
  • PROGNOSTIC-FACTOR
  • CRYPTOGENIC CIRRHOSIS
  • MASS INDEX
  • TUMOR SIZE
  • CANCER
  • PREDICTS
  • SEX
  • COMPLICATIONS

Cite this