Immunotherapy: The meta-analyses. What have we Learned?

Moisés A Calderón*, Robert J Boyle, Martin Penagos, Aziz Sheikh

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Meta-analysis is a powerful tool for evaluating the efficacy of a therapeutic intervention, and has clearly demonstrated that specific allergen immunotherapy (SIT) is effective for treating allergic rhinitis and asthma. Future research needs to focus on specifying the most effective forms of SIT for specific populations and allergens, using validated clinical outcomes, studying long-term outcomes (particularly the potential disease-modifying effect of immunotherapy), and assessing outcomes regarding health economics. The safety profile of SIT should be evaluated using international guidelines and terminology, and needs to include high-quality surveillance data.

Original languageEnglish
Pages (from-to)159-173, vii
JournalImmunology and Allergy Clinics of North America
Issue number2
Publication statusPublished - May 2011


  • Administration, Cutaneous
  • Administration, Sublingual
  • Allergens
  • Desensitization, Immunologic
  • Humans
  • Hypersensitivity
  • Treatment Outcome
  • Journal Article
  • Meta-Analysis
  • Review

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