Immunomodulation as a Potent COVID-19 Pharmacotherapy: Past, Present and Future

Decsa Medika Hertanto, Bayu Satria Wiratama, Henry Sutanto, Citrawati Dyah Kencono Wungu*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

19 Citations (Web of Science)


In the first year of its appearance, the 2019 coronavirus disease (COVID-19) has affected more than 150 million individuals and killed 3 million people worldwide. The pandemic has also triggered numerous global initiatives to tackle the newly emerging disease, including the development of SARS-CoV-2 vaccines and the attempt to discover potential pharmacological therapies. Nonetheless, despite the success of SARS-CoV-2 vac-cine development, COVID-19 therapy remains challenging. Several repurposed drugs that were documented to be useful in small clinical trials have been shown to be ineffective in larger studies. Additionally, the pathophysiology of SARS-CoV-2 infection displayed the predominance of hyperinflammation and immune dysregulation in inducing multiorgan damage. Therefore, the potential benefits of both immune modulation and suppression in COVID-19 have been extensively discussed. Here, we reviewed the roles of immunomodu-lation as potential COVID-19 pharmacological modalities based on the existing data and proposed several new immunologic targets to be tested in the foreseeable future.

Original languageEnglish
Pages (from-to)3419-3428
Number of pages10
JournalJournal of Inflammation Research
Publication statusPublished - 2021


  • COVID-19
  • immunomodulation
  • immunology
  • immune system
  • pharmacotherapy
  • coronavirus
  • drug repurposing
  • CELL

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